Intravenous lidocaine suppresses fentanyl-induced cough in Children

Cough

Musli Gashi⁴  Vlora Ismaili-Jaha³  Zorica Nikolova-Todorova²  Agreta Gecaj-Gashi¹ 

[1] Clinic of Anesthesiology & Intensive Care, University Clinical Centre of Kosova, 10000, Prishtina, Republic of Kosova;Clinic of Anesthesiology & Reanimatology and Intensive Care, University Clinical Centre of Skopje, Skopje, Republic of Macedonia;Pediatric Clinic, University Clinical Centre of Kosova, Prishtina, Republic of Kosova;Emergency Center, University Clinical Centre of Kosova, Prishtina, Kosova

关键词: General anesthesia;    Children;    Fentanyl;    Cough;    Lidocaine;   

Others  :  809234
DOI  :  10.1186/1745-9974-9-20

 received in 2013-02-11, accepted in 2013-08-12,  发布年份 2013

【 摘 要 】

Objective

Fentanyl-induced cough is usually mild and transitory, but it can be undesirable in patients with increased intracranial pressure, open wounds of the eye, dissecting aortic aneurism, pneumothorax, and reactive airway disease. The aim of this study is to evaluate the efficacy of lidocaine in suppressing fentanyl-induced cough in children during induction in general anesthesia.

Methods

One hundred and eighty-six children of both sexes, aged between 4–10 years, ASA physical status I and II, and scheduled for elective surgery, were recruited for the study. Patients with a history of bronchial asthma, obstructive pulmonary disease, or infections of the respiratory tract were excluded. Patients were randomly allocated to three equal groups (n = 62) to receive 1.0 mg/kg lidocaine (Group I), 0.5 mg/kg lidocaine (Group II), or placebo (equal volume of 0.9% saline; Group III). Each was administered over 5 s one minute before intravenous (IV) administration of fentanyl 2−3 μg/kg during induction in general anesthesia. The severity of coughing was graded by counting the number of episodes of cough: mild (1−2), moderate (3−4) or severe (5 or more).

Results

Demographic information was comparable between groups. The most frequent coughing was observed in the placebo group (Group III; 43.5%), of whom 4.8% (three patients) were graded with severe cough. In Group II, 22.6% patients had cough, of which 1.6% (one patient) was graded as severe. In Group I, 16.1% patients had cough, none of whom were graded as severe.

Conclusion

Our results demonstrate that IV lidocaine can markedly suppress fentanyl-induced cough in children, even in doses as low as 0.5 mg/kg.

【 授权许可】

   
2013 Gecaj-Gashi et al.; licensee BioMed Central Ltd.

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