Diagnostic Pathology | |
Diffuse panbronchiolitis in a patient with common variable immunodeficiency: a casual association or a pathogenetic correlation? | |
Donatella Spina1  Paola Rottoli2  Antonella Fossi2  Maria Grazia Mastrogiulio1  Marie Aimée Gloria Munezero Butorano1  David Bennett2  Aurora Barone1  Alessandro Ginori1  | |
[1] Department of Medical Biotechnologies, Pathology Unit, University of Siena, strada delle Scotte 6, Siena 53100, Italy;Respiratory Diseases and Lung Transplantation Unit, Regional Center for Sarcoidosis and other Interstitial Lung Diseases, University of Siena, viale Bracci 16, Siena 53100, Italy | |
关键词: Interstitial lung disease; Lymphocytes; Foamy macrophages; Common variable immunodeficiency; Diffuse panbronchiolitis; | |
Others : 867915 DOI : 10.1186/1746-1596-9-12 |
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received in 2013-12-09, accepted in 2014-01-10, 发布年份 2014 | |
【 摘 要 】
Diffuse panbronchiolitis (DPB) is an idiopathic inflammatory disease that seems to have an immunological pathogenesis and that causes a severe progressive suppurative and obstructive respiratory disorder. Common variable immunodeficiency (CVID) is the most common serious primary immunodeficiency and it is often associated with respiratory diseases. Herein, we describe a case of DPB in a 41-year-old man affected by CVID. We examined the patient’s lungs, focusing on the characteristics of the inflammatory cells and of the foamy macrophagic nodules typical of DPB. Immunohistochemical typing of the lymphocytic infiltrate showed that B-cells were almost absent, matching the immunological profile of CVID. The case described is the first case reported in the literature of DPB in a patient affected by CVID. Moreover it seems to confirm the correlation between an immunodeficiency status and the development of DPB and provides more information on the accumulation of nodules of foamy macrophages in DPB.
Virtual slides
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【 授权许可】
2014 Ginori et al.; licensee BioMed Central Ltd.
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