Regulation of TGF-β receptor activity

Cell & Bioscience

Ye-Guang Chen¹  Fei Huang¹ 

[1] The State Key Laboratory of Biomembrane and Membrane Biotechnology, THU-PKU Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China

关键词: degradation;    ubiquitination;    phosphorylation;    TGF-β receptor;   

Others  :  793579
DOI  :  10.1186/2045-3701-2-9

 received in 2011-12-13, accepted in 2012-03-15,  发布年份 2012

【 摘 要 】

TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β receptor activity is a critical step for signaling regulation. This review focuses on our recent understanding of regulation of TGF-β receptor activity.

【 授权许可】

   
2012 Huang and Chen; licensee BioMed Central Ltd.

【 图 表 】

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