期刊论文详细信息
Cell & Bioscience | |
Regulation of TGF-β receptor activity | |
Ye-Guang Chen1  Fei Huang1  | |
[1] The State Key Laboratory of Biomembrane and Membrane Biotechnology, THU-PKU Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China | |
关键词: degradation; ubiquitination; phosphorylation; TGF-β receptor; | |
Others : 793579 DOI : 10.1186/2045-3701-2-9 |
|
received in 2011-12-13, accepted in 2012-03-15, 发布年份 2012 | |
【 摘 要 】
TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β receptor activity is a critical step for signaling regulation. This review focuses on our recent understanding of regulation of TGF-β receptor activity.
【 授权许可】
2012 Huang and Chen; licensee BioMed Central Ltd.
【 预 览 】
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