Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis

Journal of Biomedical Science

Chunlei Tian¹  Lei Wang¹  Yuanxun Dong¹  Xiongwei Wang¹  Ran Luo¹ 

[1] Department of Neurosurgery, Institute of Neurosurgery, Yichang Central People’s Hospital & The First Clinical Medical College of Three Gorges University, Yichang, Hubei 443003, P.R. China

关键词: p53;    Signal transducer and activator of transcription 3;    Protease-activated receptor 2;    Tryptase;    Glioma;   

Others  :  820929
DOI  :  10.1186/1423-0127-21-25

 received in 2013-08-29, accepted in 2014-03-19,  发布年份 2014

【 摘 要 】

Background

The pathogenesis of glioma is unclear. The disturbance of the apoptosis process plays a critical role in glioma growth. Factors regulating the apoptosis process are to be further understood. This study aims to investigate the role of protease activated receptor-2 (PAR2) in regulation the apoptosis process in glioma cells.

Results

The results showed that U87 cells and human glioma tissue expressed PAR2. Exposure to tryptase, or the PAR2 active peptide, increased STAT3 phosphorylation in the radiated U87 cells, reduced U87 cell apoptosis, suppressed the expression of p53 in U87 cells.

Conclusions

Activation of PAR2 can reduce the radiated U87 cell apoptosis via modulating the expression of p53. The results implicate that PAR2 may be a novel therapeutic target in the treatment of glioma.

【 授权许可】

   
2014 Luo et al.; licensee BioMed Central Ltd.

【 图 表 】

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