Saturated fatty acids in human visceral adipose tissue are associated with increased 11- β-hydroxysteroid-dehydrogenase type 1 expression

Lipids in Health and Disease

Ulf Risérus³  Magnus Sundbom²  Mikael Rydén¹  Ingrid Dahlman¹  Peter Arner¹  Niklas Mejhert¹  David Edholm²  Fredrik Rosqvist³  Paul Petrus¹ 

[1] Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden;Department of Surgical Sciences, Uppsala University Hospital, Uppsala University, Uppsala, Sweden;Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

关键词: Diet;    Cortisol;    Visceral fat;    Adipose tissue;    Gene expression;    Saturated fatty acids;    11-β-hsd1;   

Others  :  1213337
DOI  :  10.1186/s12944-015-0042-1

 received in 2014-12-30, accepted in 2015-04-24,  发布年份 2015

【 摘 要 】

Background

Visceral fat accumulation is associated with metabolic disease. It is therefore relevant to study factors that regulate adipose tissue distribution. Recent data shows that overeating saturated fatty acids promotes greater visceral fat storage than overeating unsaturated fatty acids. Visceral adiposity is observed in states of hypercortisolism, and the enzyme 11-β-hydroxysteroid-dehydrogenase type 1 (11β-hsd1) is a major regulator of cortisol activity by converting inactive cortisone to cortisol in adipose tissue. We hypothesized that tissue fatty acid composition regulates body fat distribution through local effects on the expression of 11β-hsd1 and its corresponding gene (HSD11B1) resulting in altered cortisol activity.

Findings

Visceral- and subcutaneous adipose tissue biopsies were collected during Roux-en-Y gastric bypass surgery from 45 obese women (BMI; 41 ± 4 kg/m²). The fatty acid composition of each biopsy was measured and correlated to the mRNA levels of HSD11B1. 11β-hsd1 protein levels were determined in a subgroup (n = 12) by western blot analysis. Our main finding was that tissue saturated fatty acids (e.g. palmitate) were associated with increased 11β-hsd1 gene- and protein-expression in visceral but not subcutaneous adipose tissue.

Conclusions

The present study proposes a link between HSD11B1 and saturated fatty acids in visceral, but not subcutaneous adipose tissue. Nutritional regulation of visceral fat mass through HSD11B1 is of interest for the modulation of metabolic risk and warrants further investigation.

【 授权许可】

   
2015 Petrus et al.; licensee BioMed Central.

【 图 表 】

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