Correlates of serum lipoprotein (A) in children and adolescents in the United States. The third National Health Nutrition and Examination Survey (NHANES-III)

Lipids in Health and Disease

Charles N Rotimi³  Celia J Maxwell⁴  Vernon Bond¹  Abayomi S Adediran⁵  Muktar H Aliyu²  Thomas O Obisesan⁵ 

[1] Department of Human Health & Leisure Studies, Howard University, Washington, USA;Department of Epidemiology, University of Alabama at Birmingham, USA;National Human Genome Center Genetic Epidemiology Unit, Department of Microbiology, Howard University, Washington, USA;Institute for Women's Health, Howard University Hospital, Washington, USA;Section of Geriatrics, Department of Medicine, Howard University Hospital, Washington, USA

关键词: Parental History;    Ethnicity;    Gender;    Adolescence;    Lipoprotein(a);   

Others  :  1213272
DOI  :  10.1186/1476-511X-3-29

 received in 2004-11-11, accepted in 2004-12-16,  发布年份 2004

【 摘 要 】

Objective

To determine the correlates of serum lipoprotein (a) (Lp(a)) in children and adolescents in the United States.

Methods

Cross-sectional study using representative data from a US national sample for persons aged 4–19 years participating in The Third National Health Nutrition and Examination Survey (NHANES-III).

Results

We observed ethnicity-related differences in levels of Lp(a) > 30 mg/dl, with values being markedly higher in African American (black) than nonhispanic white (white) and Mexican American children in multivariate model (P < 0.001). Higher levels of Lp(a) > 30 mg/dl associated with parental history of body mass index and residence in metro compared to nonmetro in Blacks, and high birth weight in Mexican American children in the NHANES-III. In the entire group, total cholesterol (which included Lp(a)) and parental history of premature heart attack/angina before age 50 (P < 0.02) showed consistent, independent, positive association with Lp(a). In subgroup analysis, this association was only evident in white (P = 0.04) and black (P = 0.05) children. However, no such collective consistent associations of Lp(a) were found with age, gender, or birth weight.

Conclusion

Ethnicity-related differences in mean Lp(a) exist among children and adolescents in the United States and parental history of premature heart attack/angina significantly associated with levels of Lp(a) in children. Further research on the associations of Lp(a) levels in childhood with subsequent risk of atherosclerosis is needed.

【 授权许可】

   
2004 Obisesan et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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