Randomized clinical trial to evaluate the pathogenicity of Bibersteinia trehalosi in respiratory disease among calves

BMC Veterinary Research

Grant A Dewell³  Chong Wang⁴  Paul J Plummer¹  Timothy S Frana³  Vickie L Cooper³  Reneé D Dewell²  Christy J Hanthorn³ 

[1] Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA;Center for Food Security and Public Health, Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA;Department of Veterinary and Diagnostic Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 2237 Lloyd Vet Med, Ames, IA 50011, USA;Department of Statistics, College of Liberal Arts and Sciences, Iowa State University, Ames, IA 50011, USA

关键词: Pasteurellosis;    Pneumonia;    Calf;    Bovine respiratory disease;    Bibersteinia trehalosi;   

Others  :  1119236
DOI  :  10.1186/1746-6148-10-89

 received in 2013-10-23, accepted in 2014-04-11,  发布年份 2014

【 摘 要 】

Background

Bibersteinia trehalosi causes respiratory disease in ruminants particularly in wild and domestic sheep. Recently, there has been an increased number of B. trehalosi isolates obtained from diagnostic samples from bovine respiratory disease cases. This study evaluated the role of B. trehalosi in bovine respiratory disease using an intra-tracheal inoculation model in calves. Thirty six cross bred 2–3 month old dairy calves were inoculated intra-tracheally with either leukotoxin negative B. trehalosi, leukotoxin positive B. trehalosi isolate, Mannheimia haemolytica, a combination of leukotoxin negative B. trehalosi and M. haemolytica or negative control. Calves were euthanized and necropsy performed on day 10 of study.

Results

B. trehalosi inoculated calves did not have increased lung involvement compared to control calves. Additionally, B. trehalosi was only cultured once from the lungs of inoculated calves at necropsy.

Conclusions

Based on these findings B. trehalosi may not be a primary pathogen of respiratory disease in cattle. Culture of B. trehalosi from diagnostic submissions should not be immediately identified as a primary cause of respiratory disease.

【 授权许可】

   
2014 Hanthorn et al.; licensee BioMed Central Ltd.

【 图 表 】

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