Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats

Lipids in Health and Disease

Shuling Wang¹  Shuqiang Liu¹  Yuaner Zeng¹  Xiaoling Gao¹ 

[1] School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

关键词: ATP-binding cassette transporter;    Scavenger receptor BI;    Raged impairing liver;    Lipid metabolism;    Acute stress;   

Others  :  834197
DOI  :  10.1186/1476-511X-12-118

 received in 2013-06-05, accepted in 2013-07-29,  发布年份 2013

【 摘 要 】

Background

The theory of Chinese medicine believes rage harms normal liver function, namely ’raged impairing liver' in short. The purpose of this study is to investigate the impact of acute stress on liver lipid metabolism in rats.

Methods and results

Comparison of liver function indicators, serum lipid level of rats under acute stress and normal rats, as well as detection of liver tissue in the SR - BI, ABCG5 and ABCG8 protein and gene expression changes. Acute stressed rats had shown a lower serum levels of albumin (P<0.01), HDL- cholesterol (P<0.01) than normal rats, with higher serum levels of globulin (P<0.01) and LDL-cholesterol (P<0.05). Acute stressed rat’s liver tissue exhibited a lower protein expression of ABCG5 (P<0.05), ABCG8 (P<0.01) and a higher level of SR-BI (P<0.05), compared with to normal rats. Furthermore, liver gene expression of ABCG5 (P<0.01) and ABCG8 (P<0.05) were lower in acute stressed rats than in normal rats, while SR-BI was higher in acute stressed rats than in normal rats (P<0.01).

Conclusions

Acute stress had a direct influence on rat’s liver lipid metabolism.

【 授权许可】

   
2013 Gao et al.; licensee BioMed Central Ltd.

【 图 表 】

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