The covariance between relatives conditional on genetic markers

Genetics Selection Evolution

Ching Y Lin¹  Gerald B Jansen²  Yuefu Liu² 

[1] Dairy and Swine Research and Development Centre, Agriculture and Agri-Food, Canada;Department of Animal and Poultry Science, University of Guelph, Guelph, ON N1G 2W1, Canada

关键词: relationship matrix;    transmission probability;    QTL;    molecular marker;    covariance between relatives;   

Others  :  1094505
DOI  :  10.1186/1297-9686-34-6-657

 received in 2001-08-13, accepted in 2002-06-03,  发布年份 2002

【 摘 要 】

The development of molecular genotyping techniques makes it possible to analyze quantitative traits on the basis of individual loci. With marker information, the classical theory of estimating the genetic covariance between relatives can be reformulated to improve the accuracy of estimation. In this study, an algorithm was derived for computing the conditional covariance between relatives given genetic markers. Procedures for calculating the conditional relationship coefficients for additive, dominance, additive by additive, additive by dominance, dominance by additive and dominance by dominance effects were developed. The relationship coefficients were computed based on conditional QTL allelic transmission probabilities, which were inferred from the marker allelic transmission probabilities. An example data set with pedigree and linked markers was used to demonstrate the methods developed. Although this study dealt with two QTLs coupled with linked markers, the same principle can be readily extended to the situation of multiple QTL. The treatment of missing marker information and unknown linkage phase between markers for calculating the covariance between relatives was discussed.

【 授权许可】

   
2002 INRA, EDP Sciences