Herpes simplex virus and varicella zoster virus, the house guests who never leave

Herpesviridae

Robert L Hendricks²  Jean-Marc G Guedon¹  Anthony J St Leger²  Paul R Kinchington¹ 

[1]Department of Molecular Genetics & Biochemistry, University of Pittsburgh, Pittsburgh, PA, USA

[2]Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

关键词: Pathogenesis;    Immunity;    VZV;    Varicella Zoster Virus;    HSV;    Herpes Simplex Virus;    Alphaherpesvirus;   

Others  :  801065
DOI  :  10.1186/2042-4280-3-5

 received in 2011-12-16, accepted in 2012-05-12,  发布年份 2012

【 摘 要 】

Human alphaherpesviruses including herpes simplex viruses (HSV-1, HSV-2) and varicella zoster virus (VZV) establish persistent latent infection in sensory neurons for the life of the host. All three viruses have the potential to reactivate causing recurrent disease. Regardless of the homology between the different virus strains, the three viruses are characterized by varying pathologies. This review will highlight the differences in infection pattern, immune response, and pathogenesis associated with HSV-1 and VZV.

【 授权许可】

   
2012 Kinchington et al.; licensee BioMed Central Ltd.

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