Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents

Diabetology & Metabolic Syndrome

Gabriel Q Shaibi¹  Constantine S Djedjos³  Sonia Vega-López²  Justin R Ryder² 

[1] Mayo/ASU Center for Metabolic and Vascular Biology, Arizona State University, Scottsdale, AZ, USA;School of Nutrition and Health Promotion, Arizona State University, 500 N. 3rd St, Phoenix, AZ, USA;Division of Endocrinology and Diabetes, Phoenix Children’s Hospital, Phoenix, AZ, USA

关键词: Metabolic syndrome;    Insulin resistance;    Abdominal obesity;    Oxidized LDL;    Latino adolescents;   

Others  :  812479
DOI  :  10.1186/1758-5996-5-72

 received in 2013-08-28, accepted in 2013-11-13,  发布年份 2013

【 摘 要 】

Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R² = 0.13, β = -1.7; p = 0.006; R² = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R² = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents.

【 授权许可】

   
2013 Ryder et al.; licensee BioMed Central Ltd.

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