Journal of Cardiothoracic Surgery | |
Lessons learned from the use of 1,977 in-situ bilateral internal mammary arteries: a retrospective study | |
Dimitri Kalavrouziotis1  Eric Charbonneau2  Daniel Doyle2  Richard Baillot2  Eric Dumont2  Pierre Voisine2  Francois Dagenais2  Siamak Mohammadi2  | |
[1] Attending surgeon, Division of Cardiac Surgery, 2725 chemin Sainte-Foy, Quebec City G1V 4G5, QC, Canada;Division of Cardiac Surgery, Quebec Heart and Lung Institute, Quebec City, QC, Canada | |
关键词: Outcomes; Arterial grafts; Coronary artery bypass graft surgery; | |
Others : 1151750 DOI : 10.1186/s13019-014-0158-9 |
|
received in 2014-05-20, accepted in 2014-09-02, 发布年份 2014 | |
【 摘 要 】
Background
We sought to determine the early and long-term results of in-situ bilateral internal mammary artery (BIMA) grafting in patients undergoing coronary artery bypass graft surgery (CABG).
Methods
Between 1992 and 2011, 16,364 patients underwent primary isolated CABG involving at least one in-situ IMA at our institution. Among these, 1,977 patients underwent in-situ BIMA grafting: the right IMA was used to revascularize the right coronary artery system in 1,279, the circumflex system in 454 patients, and the left anterior descending (LAD) in 244. Logistic and Cox regression analyses were used to predict in-hospital mortality and cumulative late death.
Results
Late survival among BIMA patients was negatively and independently influenced by chronic obstructive pulmonary disease (hazard ratio (HR) 2.4, 95% confidence interval (CI) 1.6-3.4, p?=?0.0005), age (HR 1.2, 95% CI 1.1-1.3, p?0.001), and mediastinitis (HR 2.1, 95% CI 1.1-4.2, p?0.03). Gender, body mass index, diabetes, choice of target for the second (non-LAD) IMA, and conduit grafted to the LAD (RIMA vs. LIMA) did not influence late survival among BIMA patients. A BIMA grafting strategy was significantly beneficial for younger patients. However, it was not associated with superior late survival for patients aged 66 years and above at the time of CABG, and showed a trend to harm among octogenarians (HR 1.05, 95% CI 0.70-1.56, p?=?0.80).
Conclusions
Female gender, non-insulin dependent diabetes, and the site of second IMA anastomosis did not influence early and long-term outcomes in patients undergoing CABG with in-situ BIMA grafting. The right and left IMAs are equally effective conduits for the LAD. However, advanced age, chronic obstructive pulmonary disease, and insulin-treated diabetes mellitus have a negative impact on late survival among patients with BIMA grafts.
【 授权许可】
2014 Mohammadi et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
20150406103039315.pdf | 707KB | download | |
Figure 2. | 30KB | Image | download |
Figure 1. | 39KB | Image | download |
【 图 表 】
Figure 1.
Figure 2.
【 参考文献 】
- [1]Galbut DL, Traad EA, Dorman MJ, DeWitt PL, Larsen PB, Kurlansky PA, Carrillo RG, Gentsch TO, Ebra G: Coronary artery bypass grafting in the elderly: single versus bilateral internal mammary artery grafts. J Thorac Cardiovasc Surg 1993, 106:128-135.
- [2]Lytle BW, Blackstone EH, Sabik JF, Houghtaling P, Loop FD, Cosgrove DM: The effect of bilateral internal thoracic artery grafting on survival during 20 postoperative years. Ann Thorac Surg 2004, 78:2005-2012.
- [3]Lytle BW, Blackstone EH, Loop FD, Houghtaling PL, Arnold JH, Akhrass R, McCarthy PM, Cosgrove DM: Two internal thoracic artery grafts are better than one. J Thorac Cardiovasc Surg 1999, 117:855-872.
- [4]Tabata M, Grab JD, Khalpey Z, Edwards FH, O¿Brien SM, Cohn LH, Bolman RM 3rd: Prevalence and variability of internal mammary artery graft use in contemporary multivessel coronary artery bypass graft surgery: analysis of the society of thoracic surgeons national cardiac database. Circulation 2009, 120:935-940.
- [5]Mohammadi S, Dagenais F, Doyle D, Mathieu P, Baillot R, Charbonneau E, Perron J, Voisine P: Age cut-off for the loss of benefit from bilateral internal thoracic artery grafting. Eur J Cardiothorac Surg 2008, 33:977-982.
- [6]Taggart DP, Altman DG, Gray AM, Lees B, Nugara F, Yu LM, Campbell H, Flather M: Randomized trial to compare bilateral vs. Single internal mammary coronary artery bypass grafting: 1-year results of the arterial revascularisation trial (ART). Eur Heart J 2010, 31:2470-2481.
- [7]Taggart DP, D¿Amico R, Altman DG: The effect of arterial revascularisation on survival: a systematic review of studies comparing bilateral and single internal mammary arteries. Lancet 2001, 358:870-875.
- [8]Schmidt SE, Jones JW, Thornby JI, Miller CC, Beall AC: Improved survival with multiple left-sided bilateral internal thoracic artery grafts. Ann Thorac Surg 1997, 64:9-14.
- [9]Sabik JF 3rd, Stockins A, Nowicki ER, Blackstone EH, Houghtaling PL, Lytle BW, Loop FD: Does location of the second internal thoracic artery graft influence outcome of coronary artery bypass grafting? Circulation 2008, 118(Suppl 14):S210-S215.
- [10]Kurlansky PA, Traad EA, Dorman MJ, Galbut DL, Zucker M, Ebra G: Location of the second internal mammary artery graft does not influence outcome of coronary artery bypass grafting. Ann Thorac Surg 2011, 91:1378-1382.
- [11]Grau JB, Ferrari G, Mak AW, Shaw RE, Brizzio ME, Mindich BP, Strobeck J, Zapolanski A: Propensity matched analysis of bilateral internal mammary artery versus single left internal mammary artery grafting at 17-year follow-up: validation of a contemporary surgical experience. Eur J Cardiothorac Surg 2012, 41:770-775.
- [12]Loop FD, Lytle BW, Cosgrove DM, Mahfood S, McHenry MC, Goormastic M, Stewart RW, Golding LA, Taylor PC: J. Maxwell Chamberlain memorial paper: sternal wound complications after isolated coronary artery bypass grafting: early and late mortality, morbidity, and cost of care. Ann Thorac Surg 1990, 49:179-186.
- [13]Baillot R, Cloutier D, Montalin L, Cote L, Lellouche F, Houde C, Gaudreau G, Voisine P: Impact of deep sternal wound infection management with vacuum-assisted closure therapy followed by sternal osteosynthesis: a 15-year review of 23,499 sternotomies. Eur J Cardiothorac Surg 2010, 37:880-887.
- [14]Cosgrove DM, Lytle BW, Loop FD, Taylor PC, Stewart RW, Gill CC, Golding LA, Goormastic M: Does bilateral internal mammary artery grafting increase surgical risk? J Thorac Cardiovasc Surg 1988, 95:850-856.
- [15]Toumpoulis IK, Anagnostopoulos CE, Derose J Jr, Swistel DG: The impact of deep sternal wound infection on long-term survival after coronary artery bypass grafting. Chest 2005, 127:464-471.
- [16]Lawlor DA, Adamson J, Ebrahim S: Seven-year outcome in the bypass angioplasty revascularization investigation (BARI) by treatment and diabetic status. J Am Coll Cardiol 2000, 35:1122-1129.
- [17]Stevens LM, Carrier M, Perrault LP, Hebert Y, Cartier R, Bouchard D, Fortier A, Pellerin M: Influence of diabetes and bilateral internal thoracic artery grafts on long-term outcome for multivessel coronary artery bypass grafting. Eur J Cardiothorac Surg 2005, 27:281-288.
- [18]Boodhwani M, Lam BK, Nathan HJ, Mesana TG, Ruel M, Zeng W, Sellke FW, Rubens FD: Skeletonized internal thoracic artery harvest reduces pain and dysesthesia and improves sternal perfusion after coronary artery bypass surgery: a randomised, double-blind, within-patient comparison. Circulation 2006, 114:766-773.
- [19]Mohammadi S, Dagenais F, Mathieu P, Kingma JG, Doyle D, Lopez S, Baillot R, Perron J, Charbonneau E, Dumont E, Metras J, Desaulniers D, Voisine P: Long-term impact of diabetes and its comorbidities in patients undergoing isolated primary coronary artery bypass graft surgery. Circulation 2007, 116(Suppl 11):I220-I225.
- [20]Saxena A, Poh CL, Dinh DT, Reid CM, Smith JA, Shardey GC, Newcomb AE: Does patient gender affect outcomes after concomitant coronary artery bypass graft and aortic valve replacement? An Australian society of cardiac and thoracic surgeons database study. Cardiology 2011, 119:116-123.
- [21]Kurlansky PA, Traad EA, Dorman MJ, Galbut DL, Zucker M, Ebra G: Thirty-year follow-up defines survival benefit for second internal mammary artery in propensity-matched groups. Ann Thorac Surg 2010, 90:101-108.