Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris)

BMC Veterinary Research

Antonio Fernández¹  Josue Diaz-Delgado¹  Miguel Rivero¹  Marisa Andrada¹  Fernando Esperón²  Simona Sacchinni¹  Eva Sierra¹  Edwige N Bellière²  Manuel Arbelo¹ 

[1] Unit of Veterinary Histology and Pathology, Institute for Animal Health (IUSA), Veterinary School, University of Las Palmas de Gran Canaria, Canary Islands, Spain;Research Centre for Animal Health (CISA - INIA), Madrid, Spain

关键词: Diagnosis;    Alpha herpes virus;    Interstitial nephritis;    Beaked whale;   

Others  :  1119644
DOI  :  10.1186/1746-6148-8-243

 received in 2012-05-29, accepted in 2012-11-09,  发布年份 2012

【 摘 要 】

Background

The capacity for herpesvirus to cause disease in cetaceans is unclear and may be varied depending on the different conditions of individuals and between different species. Kidney pathology and intralesional virus-associated infection have been rarely reported in cetaceans.

Result

On April 2004, an old adult male Blainville’s beaked whale (Mesoplodon densirostris) 420 cm long with a poor body condition was stranded on Tenerife Island. During necropsy, no gross lesions were observed in the kidneys. However, membranous glomerulonephritis, multifocal interstitial lymphoplasmacytic nephritis and acute multifocal necrotizing tubulointerstitial nephritis with intranuclear inclusion bodies was diagnosed by histological analysis. Tissue samples were submitted for bacteriological analysis and molecular viral screening.

Conclusion

A novel alpha herpesvirus associated with interstitial nephritis was identified in an old adult male Blainville's beaked whale (M. densirostris) with a poor body condition stranded in the Canary Islands. This report suggests that identification of herpesvirus infection could be used as a differential diagnosis for interstitial nephritis in cetaceans.

【 授权许可】

   
2012 Arbelo et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Barr B, Dunn JL, Daniel MD, Banford A: Herpes-like viral dermatitis in a beluga whale (Delphinapferus leucas). J Wildl Dis 1989, 25:608-611.
• [2]Martineau D, Lagaci A, Beland P, Higgins R, Armstrong D, Shugart LR: Pathology of stranded beluga whales (Delphinapterus leucas) from the St. Lawrence estuary, Quebec, Canada. J Comp Pathol 1988, 98:287-311.
• [3]Kennedy S, Lindstedt IJ, McAliskey MM, McConnell SA, McCullough SJ: Herpesviral encephalitis in a harbor porpoise (Phocoena phocoena). J Zoo Wildl Med 1992, 23:374-379.
• [4]Van Bressem MF, Van Waerebeek K, Garcia-Godos A, Dekegel D, Pastoret PP: Herpes-like virus in dusky dolphins, Lagenorhynchus obscurus, from coastal Peru. Mar Mamm Sc 1994, 10:354-359.
• [5]Mikaelian I, Tremblay MP, Montpetit C, Tessaro SV, Cho HJ, House C, Measures L, Martineau D: Seroprevalence of selected viral infections In a population of beluga whales (Delphinapterus leucas) in Canada. Vet Rec 1999, 144:50-51.
• [6]Blanchard TW, Santiago NT, Lipscomb TP, Garber RL, McFee WE, Knowles S: Two novel alphaherpesviruses associated with fatal disseminated infections in Atlantic bottlenose dolphins. J Wildl Dis 2001, 37:297-305.
• [7]Arbelo M, Sierra E, Esperón F, Watanabe TT, Bellière EN, Espinosa De Los Monteros A, Fernández A: Herpesvirus infection with severe lymphoid necrosis affecting a beaked whale stranded in the Canary Islands. Dis Aquat Organ 2010, 89:261-264.
• [8]Smolarek Benson KA, Manire CA, Ewing RY, Saliki JT, Townsend FI, Ehlers B, Romero CH: Identification of novel alpha and gammaherpesviruses from cutaneous and mucosal lesions of dolphins and whales. J Virol Methods 2006, 136:261-266.
• [9]Saliki JT, Cooper EJ, Rotstein DS, Caseltine SL, Pabst DA, McLellan WA, Govett P, Harms C, Smolarek KA, Romero CH: A novel gammaherpesvirus associated with genital lesions in a Blainville’s beaked whale (Mesoplodon densirostris). J Wildl Dis 2006, 42:142-148.
• [10]van Elk CE, van de Bildt MWG, de Jong AAW, Osterhaus ADME, Kuiken T: Genital herpesvirus in bottlenose dolphins (Tursiops truncatus): cultivation, epidemiology, and associated pathology. J Wildl Dis 2009, 45:895-906.
• [11]Soto S, Gonzalez B, Willoughby K, Maley M, Olvera A, Kennedy S, Marco A, Domingo M: Systemic herpesvirus and morbillivirus Co-infection in a striped dolphin (stenella coeruleoalba). J Comp Pathol 2012, 146:269-273.
• [12]Kelly CJ, Neilson EG: Tubulointerstitial diseases. In The kidney. Edited by Brenner B, Rector F. Philadelphia, PA: W.B. Saunders Co; 1996:1655-1679.
• [13]Fernández A, Edwards JF, Rodríguez F, Espinosa De Los Monteros A, Herráez P, Castro P, Jaber JR, Martín V, Arbelo M: Gas and fat embolic syndrome involving a mass stranding of beaked whales (family ziphiidae) exposed to anthropogenic sonar signals. Vet Pathol 2005, 42:446-457.
• [14]Fernández A, Esperón F, Herraéz P, De Los Monteros AE, Clavel C, Bernabé A, Sánchez-Vizcaino JM, Verborgh P, DeStephanis R, Toledano F, Bayón A: Morbillivirus and pilot whale deaths, Mediterranean Sea. Emerg Infect Dis 2008, 14:792-794.
• [15]Esperon F, Fernandez A, Sanchez-Vizcaino JM: Herpes simplex-like infection in a bottlenose dolphin stranded in the Canary Island. Dis Aquat Organ 2008, 81:73-76.
• [16]VanDevanter DR, Warrener P, Bennett L, Schultz ER, Coulter S, Garber RL, Rose TM: Detection and analysis of diverse herpesviral species by consensus PCR. J Clin Microbiol 1996, 34:1666-1671.
• [17]Manire CA, Smolarek KA, Romero CH, Kinsel MJ, Clauss TM, Byrd L: Proliferative dermatitis associated with a novel alphaherpesvirus in an Atlantic bottlenose dolphin (Tursiops truncatus). J Zoo Wildl Med 2006, 37:174-181.
• [18]Bellière EN, Esperón F, Arbelo M, Muñoz MJ, Fernández A, Sánchez-Vizcaíno JM: Presence of herpesvirus in striped dolphins stranded during the cetacean morbillivirus epizootic along the Mediterranean Spanish coast in 2007. Arch Virol 2010, 155:1307-1311.
• [19]Maness HT, Nollens HH, Jensen ED, Goldstein T, LaMere S, Childress A, Sykes J, St Leger J, Lacave G, Latson FE, Wellehan JF Jr: Phylogenetic analysis of marine mammal herpesviruses. Vet Microbiol 2011, 149:23-29.
• [20]Miyoshi K, Nishida S, Sone E, Tajima Y, Makara M, Yoshioka M, Nakamura M, Yamada TK, Koike H: Molecular identification of novel alpha- and gammaherpesviruses from cetaceans stranded on Japanese coasts. Zoolog Sci 2011, 28:126-133.
• [21]McGeoch DJ, Rixon FJ, Davison AJ: Topics in herpesvirus genomics and evolution. Virus Res 2006, 117:90-104.
• [22]International committee on taxonomy of viruses, UK (ICTV). 2002. [http://www.ictvdb.rothamsted.ac.uk/Ictv/index.htm webcite]
• [23]Confer A, Panciera RJ: The urinary system. In Thomson’s special veterinary pathology. 3rd edition. Edited by McGavin MD, Carlton WW, Zachary JF. Mosby. St: Louis. Missouri; 2001:235-278.
• [24]Becker JL, Miller F, Nuovo GJ, Josepovitz C, Schubach WH, Nord EP: Epstein-Barr virus infection of renal proximal tubule cells: possible role in chronic interstitial nephritis. J Clin Invest 1999, 104:1673-1681.