DNA methylation signature of interleukin 1 receptor type II in asthma

Clinical Epigenetics

Catherine Laprise²  Luigi Bouchard¹  Anne-Marie Boucher-Lafleur²  Simon-Pierre Guay¹  Valérie Gagné-Ouellet² 

[1] ECOGENE-21 and Lipid Clinic, Hôpital de Chicoutimi, Saguenay, QC, Canada;Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, QC, Canada

关键词: Atopy;    Asthma;    IL1R2;    IL1R1;    IL1;    Methylation;    Epigenetics;   

Others  :  1225920
DOI  :  10.1186/s13148-015-0114-0

 received in 2015-04-30, accepted in 2015-07-13,  发布年份 2015

【 摘 要 】

Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-related phenotypes and gene expressions. We found that asthmatic and atopic individuals have higher IL1R2 promoter DNA methylation than control subjects. Additionally, we observed a negative correlation between DNA methylation at the IL1R2 promoter and IL1R2 mRNA expression. These results suggest for the first time that IL1R2 promoter DNA methylation is associated with its gene repression in allergic diseases such as asthma.

【 授权许可】

   
2015 Gagné-Ouellet et al.

【 图 表 】

Fig. 1.

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