Biphenotypic human papillomavirus-associated head and neck squamous cell carcinoma: a report of two cases

Diagnostic Pathology

Selvam Thavaraj³  Edward Odell³  Teresa Guererro Urbano²  Mary Lei²  Gayani Pitiyage¹ 

[1] Head and Neck Pathology, 4th Floor Tower Wing, Guy’s and St. Thomas’ NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK;Department of Clinical Oncology, Lower Ground Floor, Lambeth Wing, Guy’s and St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, Westminster Bridge Rd, London SE1 7EH, UK;Mucosal and Salivary Biology, King’s College London Dental Institute, 4th Floor Tower Wing, Great Maze Pond, London SE1 9RT, UK

关键词: Variant;    Undifferentiated;    Squamous cell carcinoma;    Oropharyngeal;    Human papillomavirus;    Differentiated;    Biphenotypic;    Biphasic;   

Others  :  1219339
DOI  :  10.1186/s13000-015-0334-9

 received in 2015-05-11, accepted in 2015-06-25,  发布年份 2015

【 摘 要 】

Human papillomavirus-associated oropharyngeal squamous cell carcinoma is now recognised as a subtype of head and neck cancer with distinct clinical, molecular and histological characteristics. The majority of these carcinomas are of non-keratinising squamous type but there is a growing number of histomorphologic variants of this disease. Here we describe the clinical, histomorphologic and immunophenotypic features of two cases of human papillomavirus-associated oropharyngeal squamous cell carcinoma demonstrating a clearly delineated biphasic differentiated and undifferentiated phenotype.

【 授权许可】

   
2015 Pitiyage et al.

【 图 表 】

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