Treatment envelope evaluation in transcranial magnetic resonance-guided focused ultrasound utilizing 3D MR thermometry

Journal of Therapeutic Ultrasound

Dennis L Parker²  Douglas A Christensen⁴  John W Snell³  Allison Payne²  Nick Todd²  Alexis Farrer⁵  Scott Almquist¹  Joshua de Bever¹  Henrik Odéen⁶ 

[1] School of Computing, University of Utah, Salt Lake City, Utah 84112, USA;Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, Utah 84108, USA;Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA;Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah 84112, USA;Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA;Department of Physics and Astronomy, University of Utah, Salt Lake City, Utah 84112, USA

关键词: Brain;    PRF;    MR thermometry;    tcMRgFUS;    Treatment envelope;   

Others  :  1132944
DOI  :  10.1186/2050-5736-2-19

 received in 2014-06-24, accepted in 2014-09-17,  发布年份 2014

【 摘 要 】

Background

Current clinical targets for transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) are all located close to the geometric center of the skull convexity, which minimizes challenges related to focusing the ultrasound through the skull bone. Non-central targets will have to be reached to treat a wider variety of neurological disorders and solid tumors. Treatment envelope studies utilizing two-dimensional (2D) magnetic resonance (MR) thermometry have previously been performed to determine the regions in which therapeutic levels of FUS can currently be delivered. Since 2D MR thermometry was used, very limited information about unintended heating in near-field tissue/bone interfaces could be deduced.

Methods

In this paper, we present a proof-of-concept treatment envelope study with three-dimensional (3D) MR thermometry monitoring of FUS heatings performed in a phantom and a lamb model. While the moderate-sized transducer used was not designed for transcranial geometries, the 3D temperature maps enable monitoring of the entire sonication field of view, including both the focal spot and near-field tissue/bone interfaces, for full characterization of all heating that may occur. 3D MR thermometry is achieved by a combination of k-space subsampling and a previously described temporally constrained reconstruction method.

Results

We present two different types of treatment envelopes. The first is based only on the focal spot heating—the type that can be derived from 2D MR thermometry. The second type is based on the relative near-field heating and is calculated as the ratio between the focal spot heating and the near-field heating. This utilizes the full 3D MR thermometry data achieved in this study.

Conclusions

It is shown that 3D MR thermometry can be used to improve the safety assessment in treatment envelope evaluations. Using a non-optimal transducer, it is shown that some regions where therapeutic levels of FUS can be delivered, as suggested by the first type of envelope, are not necessarily safely treated due to the amount of unintended near-field heating occurring. The results presented in this study highlight the need for 3D MR thermometry in tcMRgFUS.

【 授权许可】

   
2014 Odéen et al.; licensee BioMed Central Ltd.

【 图 表 】

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