Supplementation of highly concentrated β-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women

Lipids in Health and Disease

Masao Sato²  Bungo Shirouchi²  Hideaki Ohta¹  Katsumi Imai¹  Masako Iwamoto¹ 

[1] Graduate School of Health and Nutrition Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jounan-Ku, Fukuoka 814-0198, Japan;Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

关键词: Satsuma mandarin;    Intervention study;    Serum PAI-1;    Serum HMW-adiponectin;    β-cryptoxanthin supplementation;   

Others  :  1160311
DOI  :  10.1186/1476-511X-11-52

 received in 2012-04-20, accepted in 2012-05-04,  发布年份 2012

【 摘 要 】

Background

Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects.

Objective

We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels.

Methods

An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7 mg/day) was given to 17 moderately obese postmenopausal women.

Results

The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased.

Conclusions

We concluded that increasing the intake of β-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.

【 授权许可】

   
2012 Iwamoto et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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