Ultrasound features of medullary thyroid carcinoma correlate with cancer aggressiveness: a retrospective multicenter study

Journal of Experimental & Clinical Cancer Research

Marialuisa Appetecchia^1,11  Enrico Saggiorato³  Roberto Negro⁹  Francesco Romanelli⁴  Vito Cantisani^1,12  Ferdinando D’Ambrosio^1,12  Anna Crescenzi^1,13  Fabio Orlandi⁶  Paolo Falasca⁷  Claudio Ventura^1,10  Maurizio Latini^1,10  Giorgio Fattorini⁴  Laura Rizza^1,11  Antonella Paoloni^1,11  Francesca Rota^1,11  Agnese Barnabei^1,11  Leo Guidobaldi¹  Fabio Rossi^1,10  Nadia Cremonini⁸  Roberto Baldelli^1,11  Massimiliano Andrioli^1,14  Stefano Valabrega⁵  Luca Giovanella²  Pierpaolo Trimboli² 

[1] Section of Pathology, Ospedale Israelitico, Rome, Italy;Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;Service d’Endocrinologie, Pôle de Médecine, Centre Hospitalier des Escartons, Briançon, France;Department of Experimental Medicine, Sapienza University, Rome, Italy;Department of Medical and Surgical Sciences, Ospedale S. Andrea, Sapienza University, Rome, Italy;Section of Endocrinology, Division of Internal Medicine, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy;Internal Medicine, Ospedale S. Sebastiano Martire of Frascati, Rome, Italy;U.O.C. Endocrinology, Ospedale Maggiore, Azienda USL, Bologna, Italy;Division of Endocrinology, Ospedale V. Fazzi, Lecce, Italy;Section of Endocrinology and Diabetology, Ospedale Israelitico, Rome, Italy;Endocrinology Unit, Regina Elena National Cancer Institute, Rome, Italy;Department of Radiology, Oncology and Anatomo Pathology, Sapienza University, Rome, Italy;Pathology Unit, Campus Bio-Medico University Hospital, Rome, Italy;EndocrinologiaOggi, Rome, Italy

关键词: Thyroid nodule;    Histology;    Ultrasonography;    Medullary thyroid cancer;   

Others  :  1136105
DOI  :  10.1186/s13046-014-0087-4

 received in 2014-08-19, accepted in 2014-10-02,  发布年份 2014

【 摘 要 】

Background

Poor prognosis of medullary thyroid cancer (MTC) with suspicious ultrasound (US) features has been reported. The aim of the study was to investigate the association between preoperative US presentation and aggressiveness features of MTC. Also, US features of MTC were compared with those previously reported.

Methods

Study group comprised 134 MTC from nine different centers. Based on US presentation the nodules were stratified in “at risk for malignancy” (m-MTC) or “probably benign” (b-MTC) lesions.

Results

Eighty nine (66.4%) m-MTC and 45 (33.6%) b-MTC were found. Metastatic lymph nodes (p = 0.0001) and extrathyroid invasiveness (p < 0.0001) were more frequent in m-MTC. There was statistically significant correlation (p = 0.0002) between advanced TNM stage and m-MTC with an Odds Ratio 5.5 (95% CI 2.1–14.4). Mean postsurgical calcitonin values were 224 ± 64 pg/ml in m-MTC and 51 ± 21 in b-MTC (p = 0.003).

Conclusions

This study showed that sonographically suspicious MTC is frequently associated with features of aggressiveness, suggesting that careful preoperative US of MTC patients may better plan their surgical approach.

【 授权许可】

   
2014 Trimboli et al.; licensee BioMed Central Ltd.

【 图 表 】

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Figure 2.

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