The relationship between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus

Diabetology & Metabolic Syndrome

Yong Kyun Kim¹  Euy Jin Choi¹  Yong-Soo Kim¹  Ho Cheol Song¹  Soon Jib Yoo¹  Sung Rae Kim¹  Ji Han Yoo¹  Seong Su Lee¹  Tae Ho Kim¹ 

[1] Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

关键词: uric acid;    computed tomography;    diabetes mellitus;    adiposity;    obesity;   

Others  :  817451
DOI  :  10.1186/1758-5996-4-3

 received in 2011-09-21, accepted in 2012-02-03,  发布年份 2012

【 摘 要 】

Background

Hyperuricemia is associated with obesity. The visceral adiposity and subcutaneous adiposity may be associated with the differential metabolic risk, and the distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM) compared to healthy people. Our study was performed to determine to the association between the regional abdominal adipose tissue distribution and serum uric acid levels in people with type 2 DM.

Methods

A total of 699 people with type 2 DM and who had undergone abdominal computed tomography assessment of the visceral fat area and subcutaneous fat area were included. The serum uric acid levels were measured by the uricase method. Hyperuricemia was defined by cut-off value of > 7 mg/dl for men and > 6 mg/dl for women.

Results

The visceral fat area was positively associated with the serum uric acid levels after adjustment for age, sex, systolic blood pressure, diastolic blood pressure, serum creatinine, hemoglobin, serum albumin, serum high-density lipoprotein, serum triglyceride and hemoglobin A1c (β-coefficient = 0.117, p < 0.001). The logistic regression analysis showed that the visceral fat area was the significant independent predictor of hyperuricemia (OR 2.33, 95% CI, 1.21-4.50, p = 0.012). But there was no significant association between the subcutaneous fat area and the serum uric acid levels (β-coefficient = 0.061, p = 0.255).

Conclusions

our data shows that the visceral fat area was positively associated with the serum uric acid levels, but the subcutaneous fat area was not in people with type 2 DM.

【 授权许可】

   
2012 Kim et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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