Translation and validation of the Chinese version of the quality of life radiation therapy instrument and the head & neck module (QOL-RTI/H&N)

Health and Quality of Life Outcomes

Dong-hai Li²  Juan Sun³  Qian Xu⁵  Chuan-wei Mo⁵  Yan Liu¹  Li-zhi Liu⁷  Yong Su⁴  Mo-fa Gu⁴  Zhen-wen Qiu²  Xin-lin Chen⁶ 

[1] The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong province, China;The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong province, China;School of Human Social Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong province, China;Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong province, China;Department of Biostatistics and Preventive Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong province, China;Department of biostatistics, School of Public Health, Southern Medical University, Guangzhou, Guangdong province, China;Department of Radiology, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong province, China

关键词: Validation;    Translation;    N;    QOL-RTI/H&;    Quality of Life;    Head and neck cancer;   

Others  :  814964
DOI  :  10.1186/1477-7525-12-51

 received in 2013-10-23, accepted in 2014-04-08,  发布年份 2014

【 摘 要 】

Background

To translate and validate the Chinese version of the Quality Of Life Radiation Therapy Instrument and the Head & Neck Module (QOL-RTI/H&N), a disease-specific scale to measure quality of life (QOL) for patients with head and neck cancer (HNC) who received radiotherapy.

Methods

The QOL-RTI/H&N was translated and validated according to the standard process: a translation and back-translation procedure, pilot testing and a validation study. HNC patients were enrolled from the Cancer Center of Sun Yat-sen University and assessed using the QOL-RTI/H&N, QLQ-C30 and QLQ-H&N35. Reliability (internal consistency reliability, split-half reliability and test-retest reliability), validity (content validity, construct validity, criterion validity and discriminant validity), and responsiveness analysis were performed to evaluate the psychometric characteristics of the QOL-RTI/H&N.

Results

A total of 238 patients (99.2%) completed the questionnaire. Item RTI23 had 16.0% missing data. Other items had low percentages of missing data (0.4% or 0.8%) or no missing data. The average time to finish the scale was 9.8 minutes. Cronbach's alpha of the domains ranged from 0.41 to 0.77. The split-half reliability coefficients ranged from 0.43 to 0.77. All of the intra-class correlation coefficients were equal to or greater than 0.8. All of the item-own domain correlation coefficients were greater than those of the item-other domain. Confirmatory factor analysis showed that Comparative Fit Index, Normed Fit Index and Non-Normed Fit Index were equal to 1.00. Root Mean Square Error of Approximation was 0.01, with 90% CI (0.00, 0.10). The domain scores of the QOL-RTI/H&N were significantly correlated with those of the QLQ-C30 or QLQ-H&N3. All domain scores of patients in different radiotherapy stages were statistically significant (P < 0.05), apart from the speech domain.

Conclusions

The Chinese version of the QOL-RTI/H&N is a valid, reliable and responsive scale to measure QOL in HNC patients and can be used to assess the effects of radiotherapy treatment on these patients.

【 授权许可】

   
2014 Chen et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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