Hypoxia-regulated target genes implicated in tumor metastasis

Journal of Biomedical Science

Kou-Juey Wu²  Ya-Ping Tsai¹ 

[1] Institute of Biochemistry & Molecular Biology, National Yang-Ming University, No.155, Li-Nong St., Sec.2, Peitou, Taipei 112, Taiwan;Genome Research Center, National Yang-Ming University, Taipei 112, Taiwan

关键词: Epithelial-mesenchymal transition;    Metastasis;    Target genes;    Hypoxia-inducible factor;    Hypoxia;   

Others  :  824383
DOI  :  10.1186/1423-0127-19-102

 received in 2012-10-01, accepted in 2012-12-05,  发布年份 2012

【 摘 要 】

Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. To have a better understanding of the mechanism of hypoxia-regulated metastasis, various hypoxia/HIF-1α-regulated target genes are categorized into different classes including transcription factors, histone modifiers, enzymes, receptors, kinases, small GTPases, transporters, adhesion molecules, surface molecules, membrane proteins, and microRNAs. Different roles of these target genes are described with regards to their relationship to hypoxia-induced metastasis. We hope that this review will provide a framework for further exploration of hypoxia/HIF-1α-regulated target genes and a comprehensive view of the metastatic picture induced by hypoxia.

【 授权许可】

   
2012 Tsai and Wu; licensee BioMed Central Ltd.

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