Electrospun nanofibers as versatile interfaces for efficient gene delivery

Journal of Biological Engineering

Jae-Hyung Jang¹  Gyuhyung Jin¹  Slgirim Lee¹ 

[1] Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea

关键词: Sustained release;    Tissue engineering;    Controlled gene delivery;    Electrospun nanofibers;    Gene delivery;   

Others  :  1133608
DOI  :  10.1186/1754-1611-8-30

 received in 2014-10-14, accepted in 2014-11-27,  发布年份 2014

【 摘 要 】

The integration of gene delivery technologies with electrospun nanofibers is a versatile strategy to increase the potential of gene therapy as a key platform technology that can be readily utilized for numerous biomedical applications, including cancer therapy, stem cell therapy, and tissue engineering. As a spatial template for gene delivery, electrospun nanofibers possess highly advantageous characteristics, such as their ease of production, their ECM-analogue nature, the broad range of choices for materials, the feasibility of producing structures with varied physical and chemical properties, and their large surface-to-volume ratios. Thus, electrospun fiber-mediated gene delivery exhibits a great capacity to modulate the spatial and temporal release kinetics of gene vectors and enhance gene delivery efficiency. This review discusses the powerful characteristics of electrospun nanofibers, which can function as spatial interfaces capable of promoting controlled and efficient gene delivery.

【 授权许可】

   
2014 Lee et al.; licensee BioMed Central.

【 图 表 】

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