Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication

Cell Division

Xiaoqi Liu¹  X Shawn Liu¹  Bing Song¹ 

[1] Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA

关键词: Plk1;    phosphorylation;    ORC2;    DNA replication;   

Others  :  792738
DOI  :  10.1186/1747-1028-7-3

 received in 2011-12-21, accepted in 2012-02-06,  发布年份 2012

【 摘 要 】

Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process. It is well established that Polo-like kinase 1 (Plk1) plays critical roles in mitosis but little is known about its functions at other stages of the cell cycle. Here we summarize the functions of Plk1 during DNA replication, focusing on the molecular events related to Origin Recognition Complex (ORC), the complex that is essential for the initiation of DNA replication. Within the context of Plk1 phosphorylation of Orc2, we also emphasize regulation of Orc2 in different organisms. This review is intended to provide some insight into how Plk1 coordinates DNA replication in S phase with chromosome segregation in mitosis, and orchestrates the cell cycle as a whole.

【 授权许可】

   
2012 Song et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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