Influence of lean and fat mass on bone mineral density and on urinary stone risk factors in healthy women

Journal of Translational Medicine

Tiziana Meschi¹  Loris Borghi¹  Laura Soldati²  Elena Dogliotti²  Annalisa Terranegra²  Giuseppe Lippi³  Mario Pedrazzoni¹  Paolo Baroni⁴  Silvana Pinelli¹  Franca Allegri¹  Giuseppina Folesani¹  Angela Guerra¹  Andrea Ticinesi¹  Antonio Nouvenne¹ 

[1] Department of Clinical and Experimental Medicine, University of Parma, Via A. Gramsci 14, Parma 43126, Italy;Department of Health Sciences, Università degli Studi di Milano, Milan, Italy;Laboratory of Clinical Chemistry and Haematology, Department of Pathology and Laboratory Medicine, Parma University Hospital, Parma, Italy;Department of Mathematics, Uppsala University, Uppsala, Sweden

关键词: Urinary lithogenic risk factors;    Bone mineral density;    Fat mass;    Lean mass;    Body composition;   

Others  :  825358
DOI  :  10.1186/1479-5876-11-248

 received in 2013-06-21, accepted in 2013-10-01,  发布年份 2013

【 摘 要 】

Background

The role of body composition (lean mass and fat mass) on urine chemistries and bone quality is still debated. Our aim was therefore to determine the effect of lean mass and fat mass on urine composition and bone mineral density (BMD) in a cohort of healthy females.

Materials and methods

78 female volunteers (mean age 46 ± 6 years) were enrolled at the Stone Clinic of Parma University Hospital and subdued to 24-hour urine collection for lithogenic risk profile, DEXA, and 3-day dietary diary. We defined two mathematical indexes derived from body composition measurement (index of lean mass-ILM, and index of fat mass-IFM) and the cohort was split using the median value of each index, obtaining groups differing only for lean or fat mass. We then analyzed differences in urine composition, dietary intakes and BMD.

Results

The women with high values of ILM had significantly higher excretion of creatinine (991 ± 194 vs 1138 ± 191 mg/day, p = 0.001), potassium (47 ± 13 vs 60 ± 18 mEq/day, p < 0.001), phosphorus (520 ± 174 vs 665 ± 186 mg/day, p < 0.001), magnesium (66 ± 20 vs 85 ± 26 mg/day, p < 0.001), citrate (620 ± 178 vs 807 ± 323 mg/day, p = 0.002) and oxalate (21 ± 7 vs 27 ± 11 mg/day, p = 0.015) and a significantly better BMD values in limbs than other women with low values of ILM. The women with high values of IFM had similar urine composition to other women with low values of IFM, but significantly better BMD in axial sites. No differences in dietary habits were found in both analyses.

Conclusions

Lean mass seems to significantly influence urine composition both in terms of lithogenesis promoters and inhibitors, while fat mass does not. Lean mass influences bone quality only in limb skeleton, while fat mass influences bone quality only in axial sites.

【 授权许可】

   
2013 Nouvenne et al.; licensee BioMed Central Ltd.

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