期刊论文详细信息
Journal of Negative Results in Biomedicine
Effects of a commercial product containing guaraná on psychological well-being, anxiety and mood: a single-blind, placebo-controlled study in healthy subjects
Marco Cosentino1  Franca Marino1  Gianluca Ivan Silvestrini1 
[1] Center for Research in Medical Pharmacology, University of Insubria, Via Ottorino Rossi n. 9, Varese, VA 21100, Italy
关键词: Humans;    Mood;    Anxiety;    Psychological well-being;    Labelled instructions;    Paulinia cupana;    Guaranà;   
Others  :  812490
DOI  :  10.1186/1477-5751-12-9
 received in 2013-02-20, accepted in 2013-05-21,  发布年份 2013
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【 摘 要 】

Background

Guaranà (Paulinia cupana) seed extracts are increasingly popular worldwide for their stimulant, cognitive and behavioral effects. To assess the effects on psychological well-being, anxiety and mood of a commercially available guaranà preparation taken regularly over several days according to the labelled dosages and instructions, 27 healthy volunteers were enrolled in a prospective, randomized, single-blind, placebo-controlled, crossover study.

Results

Guaranà 350 mg × 3 daily just after breakfast or placebo were given for 5 consecutive days. Assessment was performed one day after the last intake and included the psychological well-being (PWB) scales, the self-rating anxiety state scale (SAS), and the Bond–Lader mood scales. There were no significant differences between guaranà and placebo in any of the 6 areas of PWB, in SAS, as well as in any of the 16 mood scales.

Conclusions

In healthy subjects a 5-day treatment with a commercial preparation of guaranà used according to labelled instructions provided no evidence for any major effects on psychological well-being, anxiety and mood. Considering the increasing popularity of guaranà-containing products sold as dietary supplements for fitness purposes, controlled studies are strongly warranted to assess their benefits in comparison to the labelled claims.

【 授权许可】

   
2013 Silvestrini et al.; licensee BioMed Central Ltd.

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