Centenary of Karl Jaspers’s general psychopathology: implications for molecular psychiatry

Journal of Molecular Psychiatry

Johannes Thome¹ 

[1] Department of Psychiatry, University of Rostock, Gehlsheimerstraße 20, 18147 Rostock, Germany

关键词: Theory of science;    Reductionism;    Materialism;    Philosophy;    Neuroscience;    Mind;    Methodology;    Brain;   

Others  :  815181
DOI  :  10.1186/2049-9256-2-3

 received in 2013-12-31, accepted in 2014-04-16,  发布年份 2014

【 摘 要 】

Modern molecular psychiatry benefits immensely from the scientific and technological advances of general neuroscience (including genetics, epigenetics, and proteomics). This “progress” of molecular psychiatry, however, will be to a degree “unbalanced” and “epiphytic” should the development of the corresponding theoretical frameworks and conceptualization tools that allow contextualization of the individual neuroscientific findings within the specific perspective of mental health care issues be neglected. The General Psychopathology, published by Karl Jaspers in 1913, is considered a groundbreaking work in psychiatric literature, having established psychopathology as a space of critical methodological self-reflection, and delineating a scientific methodology specific to psychiatry. With the advance of neurobiology and molecular neuroscience and its adoption in psychiatric research, however, a growing alienation between current research-oriented neuropsychiatry and the classical psychopathological literature is evident. Further, consensus-based international classification criteria, although useful for providing an internationally accepted system of reliable psychiatric diagnostic categories, further contribute to a neglect of genuinely autonomous thought on psychopathology. Nevertheless, many of the unsolved theoretical problems of psychiatry, including those in the areas of nosology, anthropology, ethics, epistemology and methodology, might be fruitfully addressed by a re-examination of classic texts, such as Jaspers’s General Psychopathology, and their further development and adaptation for 21st century psychiatry.

【 授权许可】

   
2014 Thome; licensee BioMed Central Ltd.

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