T1-mapping in the heart: accuracy and precision

Journal of Cardiovascular Magnetic Resonance

Michael S Hansen¹  Peter Kellman¹ 

[1] National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

关键词: Cardiovascular magnetic resonance;    ShMOLLI;    SASHA;    MOLLI;    Off-resonance;    ECV;    Reproducibility;    Precision;    Accuracy;    T1 map;   

Others  :  801994
DOI  :  10.1186/1532-429X-16-2

 received in 2013-11-28, accepted in 2013-12-24,  发布年份 2014

【 摘 要 】

The longitudinal relaxation time constant (T1) of the myocardium is altered in various disease states due to increased water content or other changes to the local molecular environment. Changes in both native T1 and T1 following administration of gadolinium (Gd) based contrast agents are considered important biomarkers and multiple methods have been suggested for quantifying myocardial T1 in vivo. Characterization of the native T1 of myocardial tissue may be used to detect and assess various cardiomyopathies while measurement of T1 with extracellular Gd based contrast agents provides additional information about the extracellular volume (ECV) fraction. The latter is particularly valuable for more diffuse diseases that are more challenging to detect using conventional late gadolinium enhancement (LGE). Both T1 and ECV measures have been shown to have important prognostic significance.

T1-mapping has the potential to detect and quantify diffuse fibrosis at an early stage provided that the measurements have adequate reproducibility. Inversion recovery methods such as MOLLI have excellent precision and are highly reproducible when using tightly controlled protocols. The MOLLI method is widely available and is relatively mature. The accuracy of inversion recovery techniques is affected significantly by magnetization transfer (MT). Despite this, the estimate of apparent T1 using inversion recovery is a sensitive measure, which has been demonstrated to be a useful tool in characterizing tissue and discriminating disease. Saturation recovery methods have the potential to provide a more accurate measurement of T1 that is less sensitive to MT as well as other factors. Saturation recovery techniques are, however, noisier and somewhat more artifact prone and have not demonstrated the same level of reproducibility at this point in time.

This review article focuses on the technical aspects of key T1-mapping methods and imaging protocols and describes their limitations including the factors that influence their accuracy, precision, and reproducibility.

【 授权许可】

   
2014 Kellman and Hansen; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Moon JC, Messroghli DR, Kellman P, Piechnik SK, Robson MD, Ugander M, Gatehouse PD, Arai AE, Friedrich MG, Neubauer S, Schulz-Menger J, Schelbert EB: Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson 2013, 15:92. BioMed Central Full Text
• [2]Wong TC, Piehler K, Meier CG, Testa SM, Klock AM, Aneizi AA, Shakesprere J, Kellman P, Shroff SG, Schwartzman DS, Mulukutla SR, Simon MA, Schelbert EB: Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation 2012, 126(10):1206-16.
• [3]Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS, Mulukutla SR, Simon MA, Shroff SG, Kuller LH, Schelbert EB: Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission. Eur Heart J 2013. doi: 10.1093/eurheartj/eht193
• [4]Pennell DJ, Sechtem UP, Higgins CB, et al.: Clinical indications for cardiovascular magnetic resonance (CMR): consensus panel report. Eur Heart J 2004, 25:1940-65.
• [5]Hunold P, Schlosser T, Vogt FM, et al.: Myocardial late enhancement in contrast-enhanced cardiac MRI: distinction between infarction scar and non-infarction-related disease. Am J Roentgenol 2005, 184(5):1420-6.
• [6]Sado DM, Flett AS, Moon JC: Novel imaging techniques for diffuse myocardial fibrosis. Future Cardiol 2011, 7(5):643-50.
• [7]Mewton N, Liu CY, Croisille P, Bluemke D, Lima JA: Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol 2011, 57(8):891-903.
• [8]Gai N, Turkbey EB, Nazarian S, et al.: T1 mapping of the gadolinium- enhanced myocardium: adjustment for factors affecting interpatient comparison. Magn Reson Med 2011, 65(5):1407-15.
• [9]Lee JJ, Liu S, Nacif MS, Ugander M, Kawel N, Sibley CT, Kellman P, Arai A, Bluemke DA: Myocardial T1 and extracellular volume fraction mapping at 3 tesla. J Cardiovasc Magn Reson 2011, 13(1):75. BioMed Central Full Text
• [10]Arheden H, Saeed M, Higgins CB, et al.: Measurement of the distribution volume of gadopentetate dimeglumine at echo-planar mr imaging to quantify myocardial infarction: comparison with 99mtc-dtpa autoradiography in rats. Radiology 1999, 211:698-708.
• [11]Jerosch-Herold M, Sheridan DC, Kushner JD, et al.: Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 2008, 295:H1234-42.
• [12]Flett AS, Hayward MP, Ashworth MT, et al.: Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans. Circulation 2010, 122(2):138-44.
• [13]Kehr E, Sono M, Chugh S, Jerosch-Herold M: Gadolinium-enhanced magnetic resonance imaging for detection and quantification of fibrosis in human myocardium in vitro. Int J Cardiovasc Imaging 2008, 24:61-8.
• [14]Broberg CS, Chugh S, Conklin C, Sahn DJ, Jerosch-Herold M: Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease. Circ Cardiovasc Imaging 2010, 3:727-34.
• [15]Schelbert E, Testa SM, Meier CG, et al.: Myocardial extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus. J Cardiovasc Magn Reson 2011, 13:16. BioMed Central Full Text
• [16]Ugander M, Oki AJ, Hsu L-Y, et al.: Extracellular volume imaging by MRI provides insight into overt and subclinical myocardial pathology. Eur Heart J 2012, 33(10):1268-78.
• [17]Kellman P, Wilson JR, Xue H, Bandettini WP, Shanbhag SM, Druey KM, Ugander M, Arai AE: Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience. J Cardiovasc Magn Reson 2012, 14:64. BioMed Central Full Text
• [18]Puntmann VO, Voigt T, Chen Z, Mayr M, Karim R, Rhode K, Pastor A, Carr-White G, Razavi R, Schaeffter T, Nagel E: Native T1 mapping in differentiation of normal myocardium from diffuse disease in hypertrophic and dilated cardiomyopathy. JACC Cardiovasc Imaging 2013, 6:475-84.
• [19]Messroghli DR, Niendorf T, Schulz-Menger J, Dietz R, Friedrich MG: T1 mapping in patients with acute myocardial infarction. J Cardiovasc Magn Reson 2003, 5:353-9.
• [20]Messroghli DR, Walters K, Plein S, Sparrow P, Friedrich MG, Ridgway JP, Sivananthan MU: Myocardial T1 mapping: application to patients with acute and chronic myocardial infarction. Magn Reson Med 2007, 58:34-40.
• [21]Ugander M, Bagi PS, Oki AJ, et al.: Myocardial edema as detected by pre-contrast T1 and T2 MRI delineates area at risk associated with acute myocardial infarction. JACC Cardiovasc Imaging 2012, 5(6):596-603.
• [22]Ferreira VM, Piechnik SK, Dall’Armellina E, Karamitsos TD, Francis JM, Choudhury RP, Friedrich MG, Robson MD, Neubauer S: Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2012, 14:42. BioMed Central Full Text
• [23]Dall’Armellina E, Piechnik SK, Ferreira VM, Si QL, Robson MD, Francis JM, Cuculi F, Kharbanda RK, Banning AP, Choudhury RP, Karamitsos TD, Neubauer S: Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction. J Cardiovasc Magn Reson 2012, 14:15. BioMed Central Full Text
• [24]Ferreira VM, Piechnik SK, Dall’armellina E, Karamitsos TD, Francis JM, Ntusi N, Holloway C, Choudhury RP, Kardos A, Robson MD, Friedrich MG, Neubauer S: T1 mapping for the diagnosis of acute myocarditis using CMR: comparison to T2-weighted and late gadolinium enhanced imaging. JACC Cardiovasc Imaging 2013. doi:10.1016/j.jcmg.2013.03.008 [Epub ahead of print]
• [25]Karamitsos TD, Piechnik SK, Banypersad SM, Fontana M, Ntusi NB, Ferreira VM, Whelan CJ, Myerson SG, Robson MD, Hawkins PN, Neubauer S, Moon JC: Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis. JACC Cardiovasc Imaging 2013, 6:488-97.
• [26]Puntmann VO, D’Cruz D, Smith Z, Pastor A, Choong P, Voigt T, Carr-White G, Sangle S, Schaeffter T, Nagel E: Native myocardial T1 mapping by cardiovascular magnetic resonance imaging in subclinical cardiomyopathy in patients with systemic lupus erythematosus. Circ Cardiovasc Imaging 2013, 6:295-301.
• [27]Sado DM, White SK, Piechnik SK, Banypersad SM, Treibel T, Captur G, Fontana M, Maestrini V, Flett AS, Robson MD, Lachmann RH, Murphy E, Mehta A, Hughes D, Neubauer S, Elliott PM, Moon JC: The identification and assessment of Anderson Fabry disease by cardiovascular magnetic resonance non-contrast myocardial T1 mapping. Circ Cardiovasc Imaging 2013, 6:392-8.
• [28]Pedersen SF, Thrysoe SA, Robich MP, Paaske WP, Ringgaard S, Botker HE, Hansen ES, Kim WY: Assessment of intramyocardial hemorrhage by T1-weighted cardiovascular magnetic resonance in reperfused acute myocardial infarction. J Cardiovasc Magn Reson 2012, 14:59. BioMed Central Full Text
• [29]Feng Y, He T, Carpenter J-P, Jabbour A, Alam MH, Gatehouse PD, Greiser A, Messroghli D, Firmin DN, Pennell DJ: In vivo comparison of myocardial T1 with T2 and T2* in thalassaemia major. J Magn Reson Imaging 2013, 38:588-93.
• [30]Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, Kaye DM, Taylor AJ: Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol 2008, 52:1574-80.
• [31]Flacke SJ, Fischer SE, Lorenz CH: Cardiac imaging abbreviations: gadopentetate dimeglumine partition coefficient in human myocardium in vivo: normal distribution and elevation in acute and chronic infarction. Radiology 2001, 218:703-710.
• [32]Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP: Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med 2004, 52:141-6.
• [33]Piechnik SK, Ferreira VM, Dall’Armellina E, Cochlin LE, Greiser A, Neubauer S, Robson MD: Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magn Reson 2010, 12:69. BioMed Central Full Text
• [34]Kellman P, Wilson JR, Xue H, Ugander M, Arai AE: Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method. J Cardiovasc Magn Reson 2012, 14:63. BioMed Central Full Text
• [35]Xue H, Shah S, Greiser A, et al.: Motion correction for myocardial T1 mapping using image registration with synthetic image estimation. Magn Reson Med 2012, 67(6):1644-55.
• [36]Xue H, Greiser A, Zuehlsdorff S, Jolly MP, Guehring J, Arai AE, Kellman P: Phase-sensitive inversion recovery for myocardial T(1) mapping with motion correction and parametric fitting. Magn Reson Med 2013, 69(5):1408-20.
• [37]Messroghli DR, Greiser A, Frohlich M, Dietz R, Schulz-Menger J: Optimization and validation of a fully-integrated pulse sequence for modified look- locker inversion-recovery (MOLLI) T1mapping of the heart. J Magn Reson Imaging 2007, 26:1081-6.
• [38]Gai ND, Stehning C, Nacif M, Bluemke D: Modified Look-Locker T(1) evaluation using Bloch simulations: human and phantom validation. Magn Reson Med 2013, 69(2):329-336.
• [39]Salerno M, Janardhanan R, Jiji RS, Brooks J, Adenaw N, Mehta B, Yang Y, Antkowiak P, Kramer CM, Epstein FH: Comparison of methods for determining the partition coefficient of gadolinium in the myocardium using T(1) mapping. J Magn Reson Imaging 2013, 38(1):217-224.
• [40]Kellman P, Herzka DA, Hansen MS: Adiabatic inversion pulses for myocardial T1-mapping. Magn Res Med 2013. doi:10.1002/mrm.24793. [Epub ahead of print]
• [41]Kellman P, Arai AE, Xue H: T1 and extracellular volume mapping in the heart: estimation of error maps and the influence of noise on precision. J Cardiovasc Magn Reson 2013, 15:56. BioMed Central Full Text
• [42]Kellman P, Herzka DA, Arai AE, Hansen MS: Influence of Off-resonance in myocardial T1-mapping using SSFP based MOLLI method. J Cardiovasc Magn Reson 2013, 15:63. BioMed Central Full Text
• [43]Higgins DM, Ridgway JP, Radjenovic A, Sivananthan UM, Smith MA: T1 measurement using a short acquisition period for quantitative cardiac applications. Med Phys 2005, 32:1738.
• [44]Chow K, Flewitt JA, Green JD, Pagano JJ, Friedrich MG, Thompson RB: Saturation recovery single-shot acquisition (SASHA) for myocardial T1 mapping. Magn Reson Med 2013. doi: 10.1002/mrm.24878. [Epub ahead of print]
• [45]Weingärtner S, Akçakaya M, Basha T, Kissinger KV, Goddu B, Berg S, Manning WJ, Nezafat R: Combined saturation/inversion recovery sequences for improved evaluation of scar and diffuse fibrosis in patients with arrhythmia or heart rate variability. Magn Reson Med 2013. doi: 10.1002/mrm.24761. [Epub ahead of print]
• [46]Deichmann R, Haase A: Quantification of Tl Values by SNAPSHOT-FLASH NMR Imaging. J Magn Reson 1992, 612:608-12.
• [47]Schmitt P, Griswold MA, Jakob PM, Kotas M, Gulani V, Flentje M, Haase A: Inversion recovery TrueFISP: quantification of T(1), T(2), and spin density. Magn Reson Med 2004, 51:661-667.
• [48]Song T, Stainsby JA, Ho VB, Hood MN, Slavin GS: Flexible cardiac T1 mapping using a modified Look-Locker acquisition with saturation recovery. Magn Reson Med 2012, 67:622-627.
• [49]Sung K, Nayak KS: Design and use of tailored hard-pulse trains for uniformed saturation of myocardium at 3 Tesla. Magn Reson Med 2008, 60:997-1002.
• [50]Piechnik SK, Ferreira VM, Lewandowski AJ, Ntusi NAB, Banerjee R, Holloway C, Hofman MBM, Sado DM, Maestrini V, White SK, Lazdam M, Karamitsos T, Moon JC, Neubauer S, Leeson P, Robson MD: Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI. J Cardiovasc Magn Reson 2013, 15:13. BioMed Central Full Text
• [51]Robson MD, Piechnik SK, Tunnicliffe EM, Neubauer S: T1 measurements in the human myocardium: the effects of magnetization transfer on the SASHA and MOLLI sequences. Magn Reson Med 2013, 670:664-70.
• [52]Dousset V, Degreze P, Mieze S, Sessay M, Basse-Cathalinat B, Caille J-M: Magnetization transfer on in vitro circulating blood: implications for time-of-flight angiography. JMRI 1995, 5:786-8.
• [53]Hernandez-Garcia L, Lewis DP, Moffat B, Branch CA: Magnetization transfer effects on the efficiency of flow-driven adiabatic fast passage inversion of arterial blood. NMR Biomed 2007, 20:733-42.
• [54]Pike GB, Hu BS, Glover GH, Enzmann DR: Magnetization transfer time-of-flight magnetic resonance angiography. Magn Reson Med 1992, 25:372-9.
• [55]Miller CA, Naish JH, Bishop P, Coutts G, Clark D, Zhao S, Ray SG, Yonan N, Williams SG, Flett AS, Moon JC, Greiser A, Parker GJM, Schmitt M: Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. Circ Cardiovasc Imaging 2013, 6:373-83.
• [56]Kawel N, Nacif M, Zavodni A, Jones J, Liu S, Sibley CT, Bluemke DA: T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA. J Cardiovasc Magn Reson 2012, 14:26. BioMed Central Full Text