A mammary adenocarcinoma murine model suitable for the study of cancer immunoediting

Journal of Biomedical Science

Viviana Rosa Rozados³  María José Rico²  Mariano Federico Zacarías-Fluck¹  Ricardo José Di Masso⁴  Olga Graciela Scharovsky⁴  Albertina Cardinale³  Juan Manuel Cáceres³  Lucas Pagura³ 

[1] Preclinical Research, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain;CONICET, Buenos Aires, Argentina;Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, (2000) Rosario, Argentina;CIC-UNR, Rosario, Argentina

关键词: Mathematical model;    Mammary adenocarcinoma;    Murine models;    Cancer immunoediting;   

Others  :  1137632
DOI  :  10.1186/1423-0127-21-52

 received in 2014-02-21, accepted in 2014-05-24,  发布年份 2014

【 摘 要 】

Background

Cancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune system throughout tumor development. Animal models are useful tools for studying diseases such as cancer. The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi⁻ and CBi/L inbred mice lines.

Results

The mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. CBi/L and CBi⁻ mice were artificially selected for body conformation from CBi. When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi⁻ the tumor growths briefly and then begins a rejection process in 100% of the animals. In CBi/L the growth of the tumor shows the three phases: 51.6% in ES, 18.5% in EQ and 29.8% in EL.

Conclusions

The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi⁻ and CBi/L, is a good murine model to study the process of tumor immunoediting.

【 授权许可】

   
2014 Pagura et al.; licensee BioMed Central Ltd.

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