Evaluation of the anesthetic effect of epinephrine-free articaine and mepivacaine through quantitative sensory testing

Head & Face Medicine

Ernst Marioth-Wirtz²  Jamal M Stein¹  Sareh Said Yekta-Michael² 

[1] Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Aachen University, Aachen, North Rhine-Westphalia, Germany;Interdisciplinary Center for Clinical Research, RWTH Aachen University, Aachen, North Rhine-Westphalia, Germany

关键词: Epinephrine-free;    Trigeminal region;    Maxillary infiltration;    Local anesthesia;    Mepivacaine;    Articaine;   

Others  :  1135785
DOI  :  10.1186/s13005-015-0061-1

 received in 2014-06-19, accepted in 2015-01-21,  发布年份 2015

【 摘 要 】

Introduction

Long lasting anesthesia of the soft tissue beyond the dental treatment affects patients in daily routine. Therefore a sophisticated local anesthesia is needed. The purpose of this study was an evaluation of the clinical use of epinephrine-free local anesthetic solutions in routine short-time dental treatments.

Materials and methods

In a prospective, single-blind, non-randomized and controlled clinical trial, 31 patients (16 male, 15 female patients) undergoing short-time dental treatment under local anesthesia (plain solutions of articaine 4% and mepivacaine 3%) in area of maxillary canine were tested with quantitative sensory testing QST. Paired-Wilcoxon-testing (signed-rank-test) and Mc Nemar tests have been used for statistical results.

Results

Significant differences in all tested parameters to the time of measurements were found. Mepivacaine showed a significantly stronger impact for the whole period of measurement (128 min) on thermal and mechanical test parameters and to the associated nerve fibers.

Conclusion

Plain articaine shows a faster onset of action associated with a shorter time of activity in comparison to plain mepivacaine. In addition to this articaine shows a significant low-graded effect on the tested nerve-fibers and therefore a least affected anesthesia to the patient. The clinical use of an epinephrine-free anesthetic solution can be stated as possible option in short dental routine treatments to the frequently used vasoconstrictor containing local anesthetics. Patients may benefit from shorter numbness.

【 授权许可】

   
2015 Said Yekta-Michael et al.; licensee BioMed Central.

【 图 表 】

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