Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors?

Journal of Neuroinflammation

Sharon Anavi-Goffer²  Jürg Gertsch¹ 

[1] Institute of Biochemistry and Molecular Medicine, National Centre of Competence in Research NCCR TransCure, University of Bern, Bühlstrasse 28, Bern, CH-3012, Switzerland;Departments of Behavioral Sciences and Molecular Biology, Ariel University Centre of Samaria, Ariel, 40700, Israel

关键词: Methylhonokiol;    Medicinal plant;    Magnolia grandiflora;    Endocannabinoid System;    CB₂ receptors;    Cannabinoids;    Alzheimer’s disease;   

Others  :  1212505
DOI  :  10.1186/1742-2094-9-135

 received in 2012-04-03, accepted in 2012-05-23,  发布年份 2012

【 摘 要 】

The cannabinoid type-2 G protein-coupled (CB₂) receptor is an emerging therapeutic target for pain management and immune system modulation. In a mouse model of Alzheimer’s disease (AD) the orally administered natural product 4′-O-methylhonokiol (MH) has been shown to prevent amyloidogenesis and progression of AD by inhibiting neuroinflammation. In this commentary we discuss an intriguing link between the recently found CB₂ receptor-mediated molecular mechanisms of MH and its anti-inflammatory and protective effects in AD animal models. We argue that the novel cannabimimetic MH may exert its beneficial effects via modulation of CB₂ receptors expressed in microglial cells and astrocytes. The recent findings provide further evidence for a potential role of CB₂ receptors in the pathophysiology of AD, spurring target validation and drug discovery.

【 授权许可】

   
2012 Gertsch and Anavi-Goffer.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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