Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis

Journal of Therapeutic Ultrasound

Arne Voie⁴  Eyal Zadicario³  Golnaz Ahadi⁴  David J Fisher⁴  Rema Raman¹  Thilo Hölscher² 

[1] Division of Biostatistics and Bioinformatics, University of California San Diego, San Diego, CA, 92093, USA;Department of Neurosciences, University of California San Diego, 200 West Arbor Drive, San Diego, CA, 92103-8756, USA;InSightec, Ltd, 5 Nahum Heth St., Tirat Carmel, 39120, Israel;Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, San Diego, CA, 92103, USA

关键词: Duty cycle;    Pulse width;    Stroke;    Thrombolysis;    High-intensity focused ultrasound;    Transcranial;   

Others  :  801393
DOI  :  10.1186/2050-5736-1-18

 received in 2013-04-22, accepted in 2013-08-04,  发布年份 2013

【 摘 要 】

The goal was to test the effects of various combinations of pulse widths (PW) and duty cycles (DC) on high-intensity focused ultrasound (HIFU)-induced sonothrombolysis efficacy using an in vitro flow model. An ExAblate™ 4000 HIFU headsystem (InSightec, Inc., Israel) was used. Artificial blood clots were placed into test tubes inside a human calvarium and exposed to pulsatile flow. Four different duty cycles were tested against four different pulse widths. For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001). Using transcranial HIFU, significant thrombolysis can be achieved within seconds and without the use of lytic drugs in vitro. Longer duty cycles in combination with longer pulse widths seem to have the highest potential to optimize clot lysis efficacy.

【 授权许可】

   
2013 Höelscher et al.; licensee BioMed Central Ltd.

【 图 表 】

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