CSEO – the Cigarette Smoke Exposure Ontology

Journal of Biomedical Semantics

Manuel C Peitsch³  Martin Hofmann-Apitius¹  Julia Hoeng³  Chris Coggins²  Shiva Ahmadi¹  Michaela Guendel¹  Sam Ansari³  Erfan Younesi¹ 

[1] Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Schloss Birlinghoven, 53754 Sankt Augustin, Germany;Carson Watts Consulting, 1266 Carson Watts Rd, King, NC 27021-7453, USA;Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland

关键词: Knowledge representation;    Ontology;    Environmental risk;    Cigarette smoke;    Exposure;   

Others  :  1135918
DOI  :  10.1186/2041-1480-5-31

 received in 2013-07-14, accepted in 2014-07-03,  发布年份 2014

【 摘 要 】

Background

In the past years, significant progress has been made to develop and use experimental settings for extensive data collection on tobacco smoke exposure and tobacco smoke exposure-associated diseases. Due to the growing number of such data, there is a need for domain-specific standard ontologies to facilitate the integration of tobacco exposure data.

Results

The CSEO (version 1.0) is composed of 20091 concepts. The ontology in its current form is able to capture a wide range of cigarette smoke exposure concepts within the knowledge domain of exposure science with a reasonable sensitivity and specificity. Moreover, it showed a promising performance when used to answer domain expert questions. The CSEO complies with standard upper-level ontologies and is freely accessible to the scientific community through a dedicated wiki at https://publicwiki-01.fraunhofer.de/CSEO-Wiki/index.php/Main_Page webcite.

Conclusions

The CSEO has potential to become a widely used standard within the academic and industrial community. Mainly because of the emerging need of systems toxicology to controlled vocabularies and also the lack of suitable ontologies for this domain, the CSEO prepares the ground for integrative systems-based research in the exposure science.

【 授权许可】

   
2014 Younesi et al.; licensee BioMed Central Ltd.

【 图 表 】

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