Multiscale mechanobiology: mechanics at the molecular, cellular, and tissue levels

Cell & Bioscience

Ching-Hwa Kiang²  Eric W Frey³  Sithara S Wijeratne³  Nolan C Harris³  Chin-Lin Guo¹ 

[1] Department of Bioengineering and Department of Applied Physics, California Institute of Technology, MC 138–78, Pasadena, CA 91125, USA;Department of Bioengineering, Rice University, Houston, TX, USA;Department of Physics and Astronomy, Rice University, Houston, TX, USA

关键词: Micro-patterning;    Atomic force microscopy;    Single-molecule manipulation;    Tissues;    Cells;    DNA;    Proteins;    Biomolecules;    Mechanical force;    Mechanics;   

Others  :  791645
DOI  :  10.1186/2045-3701-3-25

 received in 2013-01-07, accepted in 2013-04-24,  发布年份 2013

【 摘 要 】

Mechanical force is present in all aspects of living systems. It affects the conformation of molecules, the shape of cells, and the morphology of tissues. All of these are crucial in architecture-dependent biological functions. Nanoscience of advanced materials has provided knowledge and techniques that can be used to understand how mechanical force is involved in biological systems, as well as to open new avenues to tailor-made bio-mimetic materials with desirable properties.

In this article, we describe models and show examples of how force is involved in molecular functioning, cell shape patterning, and tissue morphology.

【 授权许可】

   
2013 Guo et al.; licensee BioMed Central Ltd.

【 图 表 】

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