Social attention: a possible early indicator of efficacy in autism clinical trials

Journal of Neurodevelopmental Disorders

Robert H Ring¹  Raphael Bernier³  Geraldine Dawson² 

[1] Department of Pharmacology and Physiology, Drexel University School of Medicine, Philadelphia, PA 19102, USA;Department of Psychology, University of Washington, Seattle, WA 98195, USA;Department of Psychiatry, University of Washington, Seattle, WA 98195, USA

关键词: Behavioral intervention;    Clinical trials;    Oxytocin;    Social attention;    Social reward;    Autism spectrum disorder;    Autism;   

Others  :  811927
DOI  :  10.1186/1866-1955-4-11

 received in 2012-01-10, accepted in 2012-05-17,  发布年份 2012

【 摘 要 】

For decades, researchers have sought to clarify the nature of the social communication impairments in autism, highlighting impaired or atypical 'social attention' as a key measurable construct that helps to define the core impairment of social communication. In this paper, we provide an overview of research on social attention impairments in autism and their relation to deficiencies in neural circuitry related to social reward. We offer a framework for considering social attention as a potential moderator or mediator of response to early behavioral intervention, and as an early indicator of efficacy of behavioral and/or pharmacological treatments aimed at addressing the social impairments in autism.

【 授权许可】

   
2012 Dawson et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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