Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report

Journal of Medical Case Reports

Murugapillai K Ragunathan¹  Gayan Ranasinghe¹  Nanthini Gnanapragash¹  Aruna Wijesinghe¹ 

[1] Ward 45, National Hospital of Sri Lanka, Colombo, Sri Lanka

关键词: Acute renal failure;    Rhabdomyolysis;    Myositis;    Dengue fever;   

Others  :  1181124
DOI  :  10.1186/1752-1947-7-195

 received in 2012-11-26, accepted in 2013-06-13,  发布年份 2013

【 摘 要 】

Introduction

With more than one-third of the world’s population living in areas at risk for transmission, dengue fever is a leading cause of illness and death in the tropics and subtropics. Despite the high incidence of dengue fever, rhabdomyolysis leading to acute renal failure is an extremely rare complication of dengue fever. Only a few such cases have been reported in the literature.

Case presentation

We describe the case of a 42-year-old, previously healthy Sri Lankan Sinhalese man who developed acute renal failure due to rhabdomyolysis following dengue virus infection. He was transferred to our institution with a five-day history of fever, headache, myalgia, impaired level of consciousness, and reduced urinary output. He was hemodynamically stable and did not have evidence of plasma leakage. His serology for dengue immunoglobulin M and immunoglobulin G was positive, and biochemical investigations disclosed evidence of rhabdomyolysis and acute renal failure. He was treated with induced alkaline diuresis and hemodialysis, and he experienced an uncomplicated recovery.

Conclusion

The occurrence of acute renal failure significantly increases the mortality of patients with dengue fever. Therefore, early diagnosis and early management are crucial in rhabdomyolysis complicating dengue fever to prevent established acute renal failure. It should be kept in mind that the threshold for suspecting rhabdomyolysis is very low in dengue fever. Creatinine phosphokinase levels should routinely be measured in all patients with severe dengue fever for early detection of rhabdomyolysis to prevent acute renal failure.

【 授权许可】

   
2013 Wijesinghe et al.; licensee BioMed Central Ltd.

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