A computerized neuropsychological test battery designed for idiopathic normal pressure hydrocephalus

Fluids and Barriers of the CNS

Jan Malm³  Michael A Williams²  Cynthia Smith¹  Eva Elgh⁵  Anders Eklund⁴  Anders Behrens³ 

[1] Division of Neuropsychology, Sinai Hospital of Baltimore, Baltimore, MD, USA;Department of Neurology, Sinai Hospital of Baltimore, Baltimore, MD, USA;Department of Clinical Neuroscience, Umeå University, Umeå, Sweden;Department of Radiation Science, Umeå University, Umeå, Sweden;Department of Clinical Sciences, Psychiatry, Umeå University, Umeå, Sweden

关键词: Software;    Reliability and validity;    Neuropsychology;    Neuropsychological tests;    Hydrocephalus, Normal pressure;    Dementia;   

Others  :  1098244
DOI  :  10.1186/2045-8118-11-22

 received in 2014-09-17, accepted in 2014-09-23,  发布年份 2014

【 摘 要 】

Background

A tool for standardized and repeated neuropsychological assessments in patients with idiopathic normal pressure hydrocephalus (INPH) is needed. The objective of this study was to develop a computerized neuropsychological test battery designed for INPH and to evaluate its reliability, validity and patient’s ability to complete the tests.

Methods

Based on a structured review of the literature on neuropsychological testing in INPH, the eight tests most sensitive to the INPH cognitive profile were implemented in a computerized format. The Geriatric Depression Scale (GDS) was also included. Tests were presented on a touch-screen monitor, with animated instructions and speaker sound. The battery was evaluated with the following cohorts: A. Test-retest reliability, 44 healthy elderly; B. Validity against standard pen and pencil testing, 28 patients with various cognitive impairments; C. Ability to complete test battery, defined as completion of at least seven of the eight tests, 40 investigated for INPH.

Results

A. All except the figure copy test showed good test-retest reliability, r = 0.67-0.90; B. A high correlation was seen between conventional and computerized tests (r = 0.66-0.85) except for delayed recognition and figure copy task; C. Seventy-eight percent completed the computerized battery; Patients diagnosed with INPH (n = 26) performed worse on all tests, including depression score, compared to healthy controls.

Conclusions

A new computerized neuropsychological test battery designed for patients with communicating hydrocephalus and INPH was introduced. Its reliability, validity for general cognitive impairment and completion rate for INPH was promising. After exclusion of the figure copy task, the battery is ready for clinical evaluation and as a next step we suggest validation for INPH and a comparison before and after shunt surgery.

Trial registration

ClinicalTrials.org NCT01265251.

【 授权许可】

   
2014 Behrens et al.; licensee BioMed Central Ltd.

【 图 表 】

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