Sinusitis and oroantral fistula in patients with bisphosphonate-associated necrosis of the maxilla

Head & Face Medicine

Philipp Poxleitner³  Gido Bittermann³  Andres Stricker³  Kiwako Izumi²  Rainer Schmelzeisen³  Gustavo Vargas Soto¹  Pit Jacob Voss³ 

[1] Department of Oral and Maxillofacial Surgery, Hospital San Juan de Dios, Universidad Latina, San José, Costa Rica;Department of Oral and Maxillofacial Surgery, Fukuoka Dental College, Fukuoka, Japan;Department of Oral and Maxillofacial Surgery, Regional Plastic Surgery, Medical Center - University of Freiburg , Hugstetter Str. 55, Freiburg im Breisgau, 79106, Germany

关键词: Purulent sinusitis;    Zoledronate;    Medication-associated necrosis of the jaws;    Nose and paranasal sinuses;   

Others  :  1235407
DOI  :  10.1186/s13005-015-0099-0

 received in 2015-06-17, accepted in 2015-12-28,  发布年份 2016

【 摘 要 】

Background

The management of bisphosphonate related necrosis of the jaw has become clinical routine. While approximately two thirds of the lesions are in the mandible, one third is located in the maxilla. In 40–50 % of maxillary necrosis the maxillary sinus is involved, leading to maxillary sinusitis and oro-antral communications.

Methods

This retrospective single center study includes all patients with diagnosis of BP-ONJ of the maxilla and concomitant maxillary sinusitis. The information collected includes age, gender, primary disease, bisphosphonate intake, involving type of bisphosphonate, route of administration and duration of BP treatment previous to surgical treatment and treatment outcome.

Results

A total of 12 patients fulfill the criteria of the diagnosis of maxillary sinusitis associated to maxillary necrosis, of which 6 Patients showed purulent sinusitis. All patients underwent surgical treatment with complete resection of the affected bone and a multilayer wound closure. A recurrence appeared in one patient with open bone and no sign of sinusitis and was treated conservatively.

Conclusions

Purulent maxillary Sinusitis is a common complication of bisphosphonate-related necrosis of the maxilla. The surgical technique described can be suggested for the treatment of these patients.

【 授权许可】

   
2016 Voss et al.

【 图 表 】

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