Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature

Diagnostic Pathology

Kevin Barry¹  Waqar Khan¹  Francis J Sullivan²  Fadel Bennani³  Tamas Nemeth³  Aisling M Hogan¹  Shane Corcoran¹ 

[1] Department of Surgery, Mayo General Hospital, Castlebar, Co. Mayo, Ireland;Department of Radiation Oncology, Galway University Hospital, Galway, Ireland;Department of Histopathology, Mayo General Hospital, Castlebar, Co. Mayo, Ireland

关键词: p53;    PR;    Progesterone receptor;    Atypical metastasis;    Cutaneous metastasis;    Scalp;    Metastatic uterine leiomyosarcoma;    Metastasis;    ULMS;    Uterine leiomyosarcoma;    Leiomyosarcoma;    Sarcoma;   

Others  :  808031
DOI  :  10.1186/1746-1596-7-85

 received in 2012-05-20, accepted in 2012-07-18,  发布年份 2012

【 摘 要 】

A 54 year old lady presented for routine excision of a scalp lesion thought clinically to represent a sebaceous cyst of the right occiput. 4 years earlier she underwent total abdominal hysterectomy and right salpingo-oophorectomy for 3 large uterine fibroids. Histo-pathological examination of the hysterectomy specimen revealed an incidental low-grade leiomyosarcoma. Staging imaging was negative for metastatic disease. She made an uneventful recovery and was treated further by adjuvant pelvic radiotherapy.

She noticed an uncomfortable and unsightly cystic swelling on her occiput four years after hysterectomy and was referred for routine excision of what was believed to be a benign lesion. The lesion was excised and sent for histopathological examination. Microscopic analysis including immuno-histochemistry demonstrated an ER and PR positive metastatic deposit of leiomyosarcoma. The margins of excision were histologically clear of disease.

At Multi-Disciplinary Team (MDT) discussion a diagnosis of metastatic scalp deposit from previous uterine leiomyosarcoma was made. Re-staging CT brain, thorax, abdomen and pelvis and MRI brain were negative for local recurrence or distant metastases. She is currently undergoing radiotherapy to the scalp and surrounding tissues and will be followed up closely by the involved teams.

To the best of our knowledge, this is the first case described in the worldwide literature of isolated cutaneous metastasis to the scalp of uterine leiomyosarcoma without evidence of disseminated disease at other sites.

【 授权许可】

   
2012 Corcoran et al.; licensee BioMed Central Ltd.

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