Clinico- pathological profile of patients with breast diseases

Diagnostic Pathology

Ribak Umah¹  Anum Mughal²  Nazish Shahid²  Hiba Arshad Shaikh²  Shafaq Saleem²  Hafiz Muhammad Aslam² 

[1] Dakshin Dinajpur District, West Bengal, Bangladesh;Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan

关键词: Fibroadenoma;    Benign breast diseases;    Breast diseases;   

Others  :  807011
DOI  :  10.1186/1746-1596-8-77

 received in 2013-04-15, accepted in 2013-05-06,  发布年份 2013

【 摘 要 】

Background

To evaluate the spectrum of breast diseases and their association with presenting complains of patients.

Methodology

It was a cross sectional study conducted from 1^st January 2010 – 30^th December 2012. A total of 254 breast specimens of patients, who were admitted in Civil Hospital Karachi with breast complaints, were included. Specimens were collected either from mastectomy, lumpectomy or needle biopsy from the admitted patients. Informed written consent was taken from all the patients. All patients with primary breast diseases were included. Patients undergoing chemotherapy or with secondary breast disease and slides with insufficient specimen were excluded. All data was entered and analyzed through SPSS 19.

Result

There were 254 breast lesions, histologically diagnosed in 3 year review period. The overall mean age of patients with breast lesion was 25.18, SD ± 11.73 with a wide age range of 12–74 years. Most common cases identified are benign 191(75.3%), followed by inflammatory 30(11.8%) and malignant lesions 30(11.8%). Most patients presenting with the complain of pain have diagnosis of fibroadenoma 24 (63.2%) while patient with complain of lump also have the most common diagnosis of fibroadenoma 147 (72.8%).

Conclusions

Study shows that in Pakistani females, mostly encountered breast lesion was fibroadenoma. Due to lack of awareness breast diseases present lately. Awareness must be created among women to reduce the mortality and morbidity with breast lesions.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1037059088969395 webcite.

【 授权许可】

   
2013 Aslam et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Malik M, Salahuddin O, Azhar M, Dilawar O, Irshad H, Sadia SA: Breast diseases; spectrum in Wah cantt; POF hospital experience. Professional Med J Sep 2010, 17(3):366-372.
• [2]Siddiqui M, Kayani N, Gill M, Pervez S, Muzaffar S, Aziz S, Setna Z, Israr M, Hasan S: Breast diseases: a histopathological analysis of 3279 cases at a tertiary care center in Pakistan. J Pak Med Assoc 2003, 53(3):94-97.
• [3]Mansoor I: Profile of female breast lesions in Saudi Arabia. JPMA 2001, 51(7):243-246.
• [4]Olu-Eddo A, Ugiagbe EE: Benign breast lesions in an African population: A 25-year histopathological review of 1864 cases. Niger J Med: J Niger Med Assoc 2011, 52(4):211.
• [5]Guray M, Sahin AA: Benign breast diseases: classification, diagnosis, and management. Oncologist 2006, 11(5):435-449.
• [6]Hislop T, Elwood J: Risk factors for benign breast disease: a 30-year cohort study. Can Med Assoc J 1981, 124(3):283.
• [7]Parazzini F, La Vecchia C, Franceschi S, Decarli A, Gallus G, Regallo M, Liberati A, Tognoni G: Risk factors for pathologically confirmed benign breast disease. Am J Epidemiol 1984, 120(1):115-122.
• [8]Berrendero F, Kieffer BL, Maldonado R: Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in μ-opioid receptor knock-out mice. J Neurosci 2002, 22(24):10935-10940.
• [9]Qin X, Peng Q, Qin A, Chen Z, Lin L, Deng Y, Xie L, Xu J, Li H, Li T: Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. Diagn Pathol 2012, 7:136. BioMed Central Full Text
• [10]Noriega M, Paesani F, Perazzo F, Lago N, Krupitzki H, Nieto S, Garcia A, Avagnina A, Elsner B, Denninghoff VC: Immunohistochemical characterization of neoplastic cells of breast origin. Diagn Pathol 2012, 7:73. BioMed Central Full Text
• [11]Morrow M: The evaluation of common breast problems. Am Fam Physician 2000, 61(8):2371-2378. 2385
• [12]Zhou WB, Xue DQ, Liu XA, Ding Q, Wang S: The influence of family history and histological stratification on breast cancer risk in women with benign breast disease: a meta-analysis. J Cancer Res Clin Oncol 2011, 137(7):1053-1060.
• [13]Mukhopadhyay P, Chakraborty S, Ponnusamy MP, Lakshmanan I, Jain M, Batra SK: Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy. Biochim Biophys Acta 2011, 1815(2):224-240.
• [14]Rakhshanda Rashid SMH, Khushal Khan , Shabana Jamal , Tanwir Khaliq , Aslam Shah : Benign breast disorders, a clinicopathological study. Ann Pak Inst Med Sci 2005, 1(4):187-190.
• [15]Muhammad Naeem Taj ZA, Hamid H, Azam Y: Pattern of presentation of breast diseases in a general hospital. Rawal Med J 2009, 34(2):124-127.
• [16]Al-Rikabi A, Husain S: Increasing prevalence of breast cancer among Saudi patients attending a tertiary referral hospital: a retrospective epidemiologic study. CMJ 2012, 53(3):239-243.
• [17]Bewtra C: Fibroadenoma in women in Ghana. PAMJ 2009, 2:11.
• [18]Jamal AA: Pattern of breast diseases in a teaching hospital in Jeddah, Saudi Arabia. Saudi Med J 2001, 22(2):110-113.
• [19]Masciadri N, Ferranti C: Benign breast lesions: ultrasound. J Ultrasound 2011, 14(2):55-65.
• [20]Adeniji KA, Adelusola KA, Odesanmi WO: Benign disease of the breast in Ile-Ife: a 10 year experience and literature review. Cent Afr J Med 1997, 43(5):140-143.
• [21]Siddiqui MS, Kayani N, Gill MS, Pervez S, Muzaffar S, Aziz SA, Setna Z, Israr M, Hasan SH: Breast diseases: a histopathological analysis of 3279 cases at a tertiary care center in Pakistan. JPMA 2003, 53(3):94-97.
• [22]Cakir A, Gonul II, Uluoglu O: A comprehensive morphological study for basal-like breast carcinomas with comparison to nonbasal-like carcinomas. Diagn Pathol 2012, 7:145. BioMed Central Full Text
• [23]Zhang Q, Zhang Q, Cong H, Zhang X: The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients. Diagn Pathol 2012, 7:181. BioMed Central Full Text
• [24]Hussain N, Bushra A, Nadia N, ZULFIQUAR A: Pattern of female breast diseases in karachi. Biomedica 2005, 21(2):36-38.
• [25]dos Santos PB, Zanetti JS, Ribeiro-Silva A, Beltrao EI: Beta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study. Diagn Pathol 2012, 7:104. BioMed Central Full Text
• [26]Talpur KAH, Laghari AA, Malik AM, Memon A: Clinico-pathological profile of patients with breast diseases at university hospital, Jamshoro. Jlumhs 2006, 5(2):71-75.
• [27]Lumachi F, Ermani M, Brandes AA, Boccagni P, Polistina F, Basso SM, Favia G, D'Amico DF: Breast complaints and risk of breast cancer. Population-based study of 2,879 self-selected women and long-term follow-up. Biomed Pharmacother 2002, 56(2):88-92.