Homoharringtonine and omacetaxine for myeloid hematological malignancies

Journal of Hematology & Oncology

Jianmin Wang¹  Shuqing Lü¹ 

[1] Department of Hematology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China

关键词: Myelodysplastic syndrome;    Acute myeloid leukemia;    Chronic myeloid leukemia;    Omacetaxine;    Homoharringtonine;   

Others  :  802235
DOI  :  10.1186/1756-8722-7-2

 received in 2013-11-08, accepted in 2013-12-26,  发布年份 2014

【 摘 要 】

Homoharringtonine (HHT), a plant alkaloid with antitumor properties originally identified nearly 40 years ago, has a unique mechanism of action by preventing the initial elongation step of protein synthesis. HHT has been used widely in China for the treatment of chronic myeloid leukemia (CML), acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Omacetaxine, a semisynthetic form of HHT, with excellent bioavailability by the subcutaneous route, has recently been approved by FDA of the United States for the treatment of CML refractory to tyrosine kinase inhibitors. This review summarized preclinical and clinical development of HHT and omacetaxine for myeloid hematological malignancies.

【 授权许可】

   
2014 Lü and Wang; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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