The association between the PPARγ2 Pro12Ala polymorphism and nephropathy susceptibility in type 2 diabetes: a meta-analysis based on 9,176 subjects

Diagnostic Pathology

Kai Yu⁴  Xin Zhao⁴  Difei Wang¹  Shuang Cai²  Zan Teng³  Lei Wang⁴ 

[1] Department of Endocrinology and Metabolism, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001, China;Department of Pharmacy, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001, China;Department of Medical Oncology, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001 China;Department of Gerontology and Geriatrics, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001 China

关键词: Polymorphisms;    Diabetic nephropathy;    Meta-analysis;    PPARγ2;   

Others  :  806096
DOI  :  10.1186/1746-1596-8-118

 received in 2013-06-29, accepted in 2013-07-03,  发布年份 2013

【 摘 要 】

Background

The polymorphism Pro12Ala in peroxisome proliferator-activated receptor­γ2 gene (PPARγ2) has been reported to be associated with diabetic nephropathy (DN) in some studies, though the results remain inconclusive. To explore this relationship between PPARγ2 Pro12Ala polymorphism and the susceptibility for DN, a cumulative meta-analysis was performed in this study.

Method

PubMed, Medline, Embase and Web of Science databases have been systematically searched to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results

18 studies were included in this meta-analysis, involving 3,361 cases and 5,815 controls. The PPARγ2 Ala12 allele was significantly associated with decreased risk of DN based on dominant model (OR=0.778; 95%CI=0.618–0.981; P_{heterogeneity}=0.008; P=0.034). In the stratified analysis by ethnicity, significantly decreased risks were found among Caucasians for dominant model (OR=0.674; 95%CI=0.500–0.909; P_{heterogeneity}=0.079; P=0.010), while there was no significant association was found in Asians.

Conclusions

The results from the present meta-analysis indicated that the Pro12Ala polymorphism in PPARγ2 gene is not a risk factor for DN in type 2 diabetes (T2D). Further large and well-designed studies are needed to confirm this conclusion.

Virtual slides

The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7491348341027320 webcite.

【 授权许可】

   
2013 Wang et al.; licensee BioMed Central Ltd.

【 图 表 】

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