Oral and general health-related quality of life in patients treated for oral cancer compared to control group

Health and Quality of Life Outcomes

Georgios Tsakos²  Blas García-Medina³  Ildefonso Martínez-Lara³  Jose Antonio Gil-Montoya¹  Manuel Bravo⁴  Rocío Barrios⁴ 

[1] Special Care in Dentistry and Gerodontology, School of Dentistry, University of Granada, C/Campus Cartuja s/n, Granada, 18071, Spain;Department of Epidemiology and Public Health, Dental Public Health, Institute of Epidemiology and Health, University College London, 1-19 Torrington Place, London WC1E6BT, UK;Oral and Maxillofacial Surgeon, Servicio de Cirugía Maxilofacial, Hospital Universitario “Virgen de las Nieves”, Avenida de las Fuerzas Armadas, 2, Granada, 18014, Spain;Preventive and Community Dentistry, School of Dentistry, University of Granada, C/Campus Cartuja s/n, Granada, 18071, Spain

关键词: OIDP;    OHIP;    SF-12;    Quality of life;    Oral cancer;   

Others  :  1133877
DOI  :  10.1186/s12955-014-0201-5

 received in 2014-10-16, accepted in 2014-12-23,  发布年份 2015

【 摘 要 】

Background

Health-related quality of life (HRQoL) is gaining importance as a valuable outcome measure in oral cancer area. The aim of this study was to assess the general and oral HRQoL of oral and oropharyngeal cancer patients 6 or more months after treatment and compare them with a population free from this disease.

Methods

A cross-sectional study was carried out with patients treated for oral cancer at least 6 months post-treatment and a gender and age group matched control group. HRQoL was measured with the 12-Item Short Form Health Survey (SF-12); oral HRQoL (OHRQoL) was evaluated using the Oral Health Impact Profile (OHIP-14) and the Oral Impacts on Daily Performances (OIDP). Multivariable regression models assessed the association between the outcomes (SF-12, OHIP-14 and OIDP) and the exposure (patients versus controls), adjusting for sex, age, social class, functional tooth units and presence of illness.

Results

For patients (n = 142) and controls (n = 142), 64.1% were males. The mean age was 65.2 (standard deviation (sd): 12.9) years in patients and 67.5 (sd: 13.7) years in controls. Patients had worse SF-12 Physical Component Summary scores than controls even in fully the adjusted model [β-coefficient = −0.11 (95% CI: −5.12-(−0.16)]. The differences in SF-12 Mental Component Summary were not statistically significant. Regarding OHRQoL patients had 11.63 (95% CI: 6.77-20.01) higher odds for the OHIP-14 and 21.26 (95% CI: 11.54-39.13) higher odds for OIDP of being in a worse category of OHRQoL compared to controls in the fully adjusted model.

Conclusion

At least 6 months after treatment, oral cancer patients had worse OHRQoL, worse physical HRQoL and similar psychological HRQoL than the general population.

【 授权许可】

   
2015 Barrios et al.; licensee BioMed Central.

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