Monosodium glutamate-induced oxidative kidney damage and possible mechanisms: a mini-review

Journal of Biomedical Science

Amod Sharma¹ 

[1] Department of Physiology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

关键词: α-Ketoglutarate dehydrogenase;    Glutamate receptors;    Oxidative stress;    Kidney;    Monosodium glutamate;   

Others  :  1232279
DOI  :  10.1186/s12929-015-0192-5

 received in 2015-08-24, accepted in 2015-10-06,  发布年份 2015

【 摘 要 】

Animal studies suggest that chronic monosodium glutamate (MSG) intake induces kidney damage by oxidative stress. However, the underlying mechanisms are still unclear, despite the growing evidence and consensus that α-ketoglutarate dehydrogenase, glutamate receptors and cystine-glutamate antiporter play an important role in up-regulation of oxidative stress in MSG-induced renal toxicity. This review summaries evidence from studies into MSG-induced renal oxidative damage, possible mechanisms and their importance from a toxicological viewpoint.

【 授权许可】

   
2015 Sharma.

【 图 表 】

Fig. 1.

Fig. 2.

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