Topical allogeneic platelet-rich plasma treatment for a massive cutaneous lesion induced by disseminated intravascular coagulation in a toy breed dog

Irish Veterinary Journal

Chul Park³  Jin-ho Park³  Namjung Kim¹  Dae-seung Baek³  Tae-ho Chung² 

[1] National Academy of Agriculutral Science, Gyeonggi 441-707, Republic of Korea;Department of Animal Resources Science, Joongbu University, Chungnam 312-702, Republic of Korea;Department of Veterinary Internal Medicine, BK21 Plus, Chonbuk National University, Jeonbuk 561-756, Republic of Korea

关键词: Topical treatment;    Toy breed dog;    Cutaneous lesion;    Disseminated intravascular coagulation;    Platelet-rich plasma;   

Others  :  1135790
DOI  :  10.1186/s13620-015-0032-7

 received in 2014-04-29, accepted in 2015-01-23,  发布年份 2015

【 摘 要 】

A 2-year-old intact female miniature Pinscher weighing 1.7 kg with a body condition score of 2/5 was presented for acute vomiting, lethargy for 2 days, and large petechial skin lesions on the hip region including the tail. Acute pancreatitis was diagnosed by clinical signs, strong positive cPLI test, laboratory test and ultrasound appearance. While the clinical signs associated with acute pancreatitis had improved in 3–5 days, lesion of petechial appeared on the left hip region 7 days after the presentation, with a fast progression into a necrotic tissue along the left side hip. Allogenic platelet rich plasma (PRP) with Weibrich and Kleis method was administered to promote skin healing and regeneration. Gradual and complete improvement in the dog’s wound lesions was noted approximately 1 month after applying allogeneic topical PRP. In this case report, allogeneic PRP was applied to a large regional cutaneous defect caused by coagulopathy induced by acute pancreatitis. Topical application of PRP in this case was unique in that allogeneic PRP was used instead of autologous PRP for the first time in cutaneous soft-tissue wound management in the veterinary medical field.

【 授权许可】

   
2015 Chung et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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