Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits

BMC Veterinary Research

György Csikó¹  Csaba Juhász²  Zoltán Somogyi¹  Zoltán Dinya⁵  Paul Clayton³  János Gál⁴  Orsolya Palócz¹ 

[1]Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent István University, István u. 2, Budapest 1078, Hungary

[2]Immitec Nutrition AB, Farmannsveien 18-22, Tønsberg 3111, Norway

[3]Institute for Food, Brain and Behaviour, 106-108. Cowley Road, Oxford, UK

[4]Department of Exotic Animal and Wildlife Medicine, Faculty of Veterinary Science, Szent István University, István u. 2, Budapest 1078, Hungary

[5]Flavon Group Hungary, Veres Péter u. 19, Debrecen 4033, Hungary

关键词: Rabbit;    β-glucan;    Pasteurella multocida;   

Others  :  1103411
DOI  :  10.1186/s12917-014-0276-6

 received in 2014-05-27, accepted in 2014-11-10,  发布年份 2014

【 摘 要 】

Background

Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunisation is only variably effective. Prophylactic antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species.

Results

Thirthy-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1–3), (1–6) β-glucans or placebo. Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1–3), (1–6) β-glucans, antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics.

Conclusions

In our study, (1–3), (1–6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times in the supra-physiological model. Enrofloxacin was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined prophylaxis.

【 授权许可】

   
2014 Palócz et al.; licensee BioMed Central Ltd.

【 图 表 】

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