Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol

Journal of Translational Medicine

Xiangdong Wang⁴  Yong-fang Yuan¹  Qiu-wei Fan²  Juan Li³  Bing Chen³  Hong-bin Gu⁵  Wan-hua Yang³ 

[1] Department of Pharmacy, The Third Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China;Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;Department of Respiratory Medicine, Fudan University Zhongshan Hospital, China;Department of Anesthesiology, Shanghai Children′s Medical Centre, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

关键词: drug delivery system, pediatric, evaluation;    high performance liquid chromatography;    plasma concentration;    Propofol;   

Others  :  1207831
DOI  :  10.1186/1479-5876-9-187

 received in 2011-07-15, accepted in 2011-11-01,  发布年份 2011

【 摘 要 】

Background

The target-controlled infusion-III (SLOG/TCI-III) system was derived from a model set up by the local pediatric population for target control infusion of propofol.

Methods

The current study aimed at evaluating the difference between target concentrations of propofol and performance, which was measured using the SLOG/TCI-III system in children. Thirty children fulfilling the I-II criteria according to American Society of Anesthesiology were enrolled in the study. The target plasma concentration of propofol was fed into the SLOG/TCI-III system and compared with the measured concentrations of propofol. Blood samples were collected and analyzed by high performance liquid chromatography with fluorescence detector. The performance error (PE) was determined for each measured blood propofol concentration. The performances of the TCI-III system were determined by the median performance error (MDPE), the median absolute performance error (MDAPE), and Wobble (the median absolute deviation of each PE from the MDPE), respectively.

Results

Concentration against target concentration showed good linear correlation: concentration = 1.3428 target concentration - 0.2633 (r = 0.8667). The MDPE and MDAPE of the pediatric system were 10 and 22%, respectively, and the median value for Wobble was 24%. MDPE and MDAPE were less than 15 and 30%, respectively.

Conclusions

The performance of TCI-III system seems to be in the accepted limits for clinical practice in children.

【 授权许可】

   
2011 Yang et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 2.

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