Acute kidney injury associated with minimal change disease in systemic lupus erythematosus: a case report

Journal of Medical Case Reports

Qinkai Chen²  Hongping Wan¹  Luxia Tu¹  Ying Wang²  Xin Wei² 

[1] Department of Pathology, The First Affiliated Hospital, Nan Chang University, YongWai street 17#, Nanchang city 330006, China;Department of Nephrology, The First Affiliated Hospital, Nan Chang University, YongWai street 17#, Nanchang city, Jiangxi province 330006, China

关键词: Systemic lupus erythematosus;    Minimal change disease;    Acute kidney injury;   

Others  :  1180931
DOI  :  10.1186/1752-1947-8-422

 received in 2014-05-18, accepted in 2014-10-15,  发布年份 2014

【 摘 要 】

Introduction

In systemic lupus erythematosus, acute kidney injury is usually associated with severe lupus nephritis and rarely associated with other glomerular diseases.

Case presentation

We recently encountered a patient with acute kidney injury that was associated with minimal change disease in systemic lupus erythematosus. A 26-year-old Chinese woman who had a history of systemic lupus erythematosus presented with nephrotic syndrome and acute kidney injury. She fulfilled four of the American College of Rheumatology criteria for the classification of systemic lupus erythematosus. However, a renal biopsy revealed that there were no glomerular abnormalities or deposition of immune complex. Her generalized edema disappeared, and her high serum creatinine level decreased to normal after prednisolone therapy.

Conclusion

Though the relationship between lupus and minimal change disease is still not defined, the possibility of systemic lupus erythematosus combined with minimal change disease must be differentiated in patients with lupus and severe proteinuria.

【 授权许可】

   
2014 Wei et al.; licensee BioMed Central.

【 图 表 】

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