Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation

Cell Division

Anne Baron-Van Evercooren²  Céline Caillava¹ 

[1] Cnrs, UMR 7225, Paris, France;AP-HP Hôpital Pitié-Salpêtrière, Fédération de Neurologie, Paris, France

关键词: Adult neural stem cell;    Oligodendrocyte progenitor;    Remyelination;    Proliferation;    Cdk2;   

Others  :  791247
DOI  :  10.1186/1747-1028-7-14

 received in 2011-10-07, accepted in 2012-04-18,  发布年份 2012

【 摘 要 】

Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2-cyclin E complexes, phosphorylating the retinoblastoma protein, drive cells through the G1/S transition into the S phase of the cell cycle. Despite its fundamental role, Cdk2 was found to be indispensable only in specific cell types due to molecular redundancies in its function. Converging studies highlight involvement of Cdk2 and associated cell cycle regulatory proteins in oligodendrocyte progenitor cell proliferation and differentiation. Giving the contribution of this immature cell type to brain plasticity and repair in the adult, this review will explore the requirement of Cdk2 for oligodendrogenesis, oligodendrocyte progenitor cells proliferation and differentiation during physiological and pathological conditions.

【 授权许可】

   
2012 Caillava and Baron-Van Evercooren; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

Figure 2 .

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