Health and Quality of Life Outcomes | |
Mapping of Incontinence Quality of Life (I-QOL) scores to Assessment of Quality of Life 8D (AQoL-8D) utilities in patients with idiopathic overactive bladder | |
Jeffrey Richardson1  Angelo Iezzi1  Kwong Ng2  Jonathan T Tan4  Gang Chen3  | |
[1] Centre for Health Economics, Monash University, Melbourne, Australia;Allergan Pty Ltd, Pasir Panjang, Singapore;Flinders Health Economics Group, School of Medicine, Flinders University, Adelaide, Australia;Allergan Pty Ltd, Level 4, 810 Pacific Highway. Gordon, Melbourne, NSW 217, Australia | |
关键词: Utility; Cross-walk; Mapping; AQoL; I-QOL; HRQOL; Overactive bladder; Urinary incontinence; | |
Others : 1164530 DOI : 10.1186/s12955-014-0133-0 |
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received in 2014-05-09, accepted in 2014-08-14, 发布年份 2014 | |
【 摘 要 】
Background
The Incontinence Quality of Life (I-QOL) questionnaire is a commonly used and validated incontinence specific QOL instrument. The objective of this study is to develop an algorithm to map I-QOL to the Assessment of Quality of Life (AQoL) 8D utility instrument in patients with idiopathic overactive bladder (iOAB).
Methods
I-QOL and AQoL-8D scores were collected in a survey of 177 Australian adults with urinary incontinence due to iOAB. Three statistical methods were used for estimation, namely ordinary least squares (OLS) regression, the robust MM-estimator, and the generalised linear models (GLM). Each included a range of explanatory variables. Model performance was assessed using key goodness-of-fit measures in the validation dataset.
Results
The I-QOL total score and AQoL-8D utility scores were positively correlated (r?=?0.50, p?0.0001). Similarly, the three sub-scales of the I-QOL were correlated with the eight dimensions and two super-dimensions of the AQoL-8D. The GLM estimator, with I-QOL total score as the explanatory variable exhibited the best precision (MAE?=?0.15 and RMSE?=?0.18) with a mapping function given by AQoL-8D?=?exp(?1.28666?+?1.011072*I-QOL/100).
Conclusions
The mapping algorithm developed in this study allows the derivation of AQoL-8D utilities from I-QOL scores. The algorithm allows the calculation of preference-based QOL scores for use in cost-utility analyses to assess the impact of interventions in urinary incontinence.
【 授权许可】
2014 Chen et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20150415091957918.pdf | 264KB | download | |
Figure 2. | 40KB | Image | download |
Figure 1. | 22KB | Image | download |
【 图 表 】
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