Adrenal cortical carcinoma with extension into the inferior vena cava – case report and literature review

Diagnostic Pathology

Agnieszka Halon²  Dariusz Patrzalek¹  Lukasz Fulawka³ 

[1] Department of Surgery, 4th Military Clinical Hospital in Wroclaw, ul. Weigla 5, 50-981 Wrocław, Poland;Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland;Department of Pathomorphology, Lower Silesian Oncology Centre, pl. Hirszfelda 12, 53-413 Wroclaw, Poland

关键词: Van Slooten criteria;    Weiss criteria;    Adrenocortical tumour;    Adrenocortical carcinoma;    Adrenal cortical carcinoma;   

Others  :  802621
DOI  :  10.1186/1746-1596-9-51

 received in 2013-10-07, accepted in 2014-03-03,  发布年份 2014

【 摘 要 】

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an incidence rate of 1 to 2 per million person-years. ACC most commonly arises sporadically, but may be associated with familial tumour syndromes. Clinical symptoms are mainly related to an excess of steroid hormones. We present an unusual case of adrenocortical carcinoma in a 27-year-old male who complained of non specific mass-effect related symptoms of slowly growing intensity differing from others described in literature because of the patient’s age and the sudden deterioration of the clinical course. The tumour was resected with the left kidney with an extension into the inferior vena cava. Histological examination revealed morphological features characteristic of an adrenal cortical tumour. The immunohistochemical results (positive reactions for vimentin, CD56, inhibin, melan A, synaptophysin, bcl-2, calretinin) confirmed the diagnosis. According to the most widely used modified Weiss criteria and the Van Slooten system, a diagnosis of adrenal cortical carcinoma was strongly confirmed. The postoperative condition was poor. Reoperation was conducted, including abdominal aorta thrombectomy and aortic prosthesis implantation. The patient died two days after the second operation. Autopsy revealed a metastatic tumour in the left lung and morphological symptoms of acute circulatory collapse due to a massive haemorrhage into the abdominal cavity, which was the direct cause of death.

Virtual slides

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【 授权许可】

   
2014 Fulawka et al.; licensee BioMed Central Ltd.

【 图 表 】

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